ISMRM22 - Perfusion MRI for Mapping Neurofluid Circulation & Exchange

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

Perfusion MRI for Mapping Neurofluid Circulation & Exchange

Member-Initiated Symposium

Wednesday, 11 May 2022

ICC Capital Hall 2

14:30 - 16:30

Session Number: MIS-07

Maria Fernandez-Seara, and Ben Statton

Overview
The circulation of neurofluids including blood and cerebrospinal fluid (CSF) within the CNS and their exchange across the blood-brain barrier (BBB) and Blood CSF Barrier (BCSFB) are critical for maintaining the normal brain function. These functions are tightly related to the glymphatic system for the clearance of brain waste. During recent years, innovative contrast and noncontrast perfusion MRI methods have been introduced for visualizing and quantifying neurofluid circulation and exchange within the CNS. This topic is highly relevant to the theme of ISMRM for cardiovascular imaging. In this symposium organized by perfusion SG, Dr. Mai-Lan Ho will first provide an overview of neurofluid circulation in the CNS. Dr. Jack Wells will introduce new perfusion MRI methods for mapping water exchange across the BBB and BCSFB, and Dr. Manus Donahue will present choroid plexus perfusion imaging using arterial spin labeling with clinical applications. Dr. Swati Rane will then summarize recent progresses for in vivo imaging of glymphatic system based on dynamic contrast MRI. Finally, Dr. Jun Hua will present a novel dynamic contrast MRI approach to map CSF circulation with high spatial and temporal resolutions. Finally, Dr. Ben Sinclair will present automated perivascular space identification and application to clinical populations (traumatic brain injury, post-stroke epilepsy, dementia and multiple sclerosis). The 6 speakers and 3 organizers are leaders of the field at different career levels, with diverse backgrounds (MD and PhD, ISMRM and SMRT) and international representations (North America and Europe). Finally, the audience will have opportunities to interact with the speakers.

Target Audience
Scientists, engineers, clinical researchers and neuro-radiologists interested in mapping neurofluid circulation and exchange in the CNS using MRI.

Educational Objectives
As a result of attending this course, participants should be able to:
Understand the neuroanatomy and physiology of cerebral blood supply and CSF production and circulation;
Learn the state-of-the-art perfusion MRI techniques and their applications for mapping the circulation of neurofluids through the CNS;
Recognize the potentials and challenges of these emerging perfusion MRI measurements of neurofluid circulation and exchange;
Identify the suitable clinical applications and associated barriers need to be overcome for the translation of perfusion MRI for in vivo mapping of glymphatic system.

	14:30		Neurofluid Circulation in the CNS Video Unavailable Mai-Lan Ho Nationwide Children’s Hospital
	14:50		Mapping Water Exchange Across BBB & BCSFB Video Unavailable Jack Wells University of College London, United Kingdom
	15:10		Choroid Plexus Perfusion Imaging Video Unavailable Manus Donahue Vanderbilt University
	15:30		In Vivo Imaging of Glymphatic System with Dynamic Contrast MRI Video Unavailable Swati Rane Levendovszky University of Washington
	15:50		Optimization of DSC & DCE MRI for the Measurement of Gd Induced Dynamic Signal Changes in the CSF Video Unavailable Jun Hua Johns Hopkins University
	16:10		Automated Perivascular Space Identification & Application to Clinical Populations Video Unavailable Ben Sinclair