ISMRM22 - Macromolecular Proton Fraction (MPF) from Scratch: Practical Guide on Protocols & Software Tools</span></div>

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

Macromolecular Proton Fraction (MPF) from Scratch: Practical Guide on Protocols & Software Tools

Member-Initiated Tutorials

Wednesday, 11 May 2022

ICC Capital Suite 14-16

09:15 - 11:15

Session Number: MIT-03

Anna Naumova, and Neva Corrigan.

Overview
The macromolecular proton fraction (MPF) is a key parameter describing the magnetization transfer (MT) effect. In the past decade, MPF has attracted remarkable attention as a quantitative imaging biomarker of myelin due to its high sensitivity to demyelination and strong correlations between MPF and myelin content in neural tissues. Practical advantages of MPF include independence of magnetic field strength, insensitivity to iron deposition, high reproducibility, time-efficient data acquisition, and the feasibility of protocol harmonization across MRI platforms of different manufacturers. The proposed tutorial is focused on live demonstration of the three open-source software tools for MPF mapping based on different MT models and reconstruction algorithms including the general quantitative MT analysis and simulation tool implemented in qMRLab software, standalone software for serial MPF map reconstruction based on the single-point algorithm, and the dedicated tool for evaluation and optimization of MPF acquisition and reconstruction algorithms. The training sessions will provide practical guidance on the design of appropriate imaging protocols, installation, configuration, and troubleshooting for each software followed by a Q&A session. The tutorial will enable potential users to choose an appropriate to their research MPF mapping technique, implement the entire workflow, and integrate MPF map reconstruction into more complex image processing pipelines.

Target Audience
Researchers and clinicians interested in quantitative MRI techniques for neuroscience

Educational Objectives
As a result of attending this course, participants should be able to:
• Knowledge of the methodological background and reconstruction algorithms for fast clinically targeted mapping of the macromolecular proton fraction (MPF).|• Familiarity with MPF mapping and quantitative MT software usage.|• Step-by-step practical skills in implementation of fast MPF mapping for myelin quantification in human brain.

	09:15		Standalone Software for Reconstruction of MPF Maps Using the Single-Point Algorithm: Hands-on Training with Multi-Platform Data Video Unavailable Vasily Yarnykh University of Washington
	09:45		A Flexible MATLAB Framework for Evaluation & Optimization of MPF Acquisition & Reconstruction Algorithms Video Unavailable Aleksey Samsonov University of Wisconsin – Madison
	10:15		A Scanner to Publication Workflow for Magnetization Transfer Imaging Using qMRLab Video Unavailable Nikola Stikov Polytechnique Montreal, Canada
	10:45		Live demos: Systems and Components