ISMRM22 - Thursday Plenary

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

Thursday Plenary

Plenary Session

ORGANIZERS: Mark Chiew, Richard Bowtell, Sune Jespersen, Ashley Harris

Thursday, 12 May 2022

Plenary: ICC Auditorium

11:30 - 13:15

Moderators: Mark Chiew & Richard Bowtell

Session Number: P-04

Session Number: P-04

Overview
This plenary is centered around ideas or papers that had a large gap between their original publication dates and their impact (which may be either scientific or clinical), for any number of reasons (hardware catching up, novel applications of the concept recently discovered, or just wasn't appreciated at the time for whatever reason).

The basic concept would be to have the speakers provide some context for the original idea, why it was so novel for the time, reasons why it didn’t take off initially, and why it’s come back in a big way now. Speakers will also be asked to discuss the value of research ideas that don’t have immediate applications or obvious translational aspects and to reflect on the benefits of supporting “blue-sky” research alongside research with immediate clinical impact.

Target Audience
With 3 diverse topic areas, we target a wide audience with interest in scientific innovation.

Through the discussion of previous innovations, this session aims to inspire new scientific discovery that may or may not have an immediate application, but which will be valued in the long term.

Educational Objectives
As a result of attending this course, participants should be able to:
- Examine the context for the early innovations of resting-state fMRI, balanced steady-state free precession, and deuterium imaging;
- Explain the reasons why these ideas were not immediately translated to their widespread implementation; and
- Describe the impact of these ideas today and their increasing future impact.

	11:30		Young Investigators Award Presentation View the Presentation Scott Reeder
	12:15		Resting-State Brain Connectivity I View the Presentation Bharat Biswal
	12:25		Resting-State Brain Connectivity II: Applications and Future Directions View the Presentation Juan Helen Zhou
	12:35		bSSFP I View the Presentation Karla Miller
	12:45		bSSFP II View the Presentation Ruth Lim Balanced steady state free precession (b-SSFP) imaging was described in 1958 and has become an invaluable MRI sequence with applications in cardiac and vascular imaging, and also for other regions. Some examples demonstrating the versatility and clinical usage of b-SSFP will be presented.
	12:55		Deuterium I: Back to the Past View the Presentation Joseph Ackerman Deuterium (²H=D) is a stable, non-toxic isotope of hydrogen, whose use as a ¹H-MRI contrast agent was first proposed by Mansfield and Morris in 1982. Alternatively, ²H can be detected directly. Throughout the late 1980s and 1990s, ²H-MR in vivo focused on D₂O (heavy water) as a perfusion tracer. However, a 1987 article did report that ²H resonances from metabolic products of administered ²H-labelled substrates (glucose, acetate) could be observed in vivo. Nevertheless, the field went quiet for two decades until a surge of recent activity. This lecture will review the early history and subsequent dormancy of ²H-MRI.
	13:05		Deuterium Metabolic Imaging: Back to the Future View the Presentation Robin de Graaf Deuterium metabolic imaging (DMI) is a robust MR-based method to image active metabolism non-invasively in vivo. The metabolic conversion of deuterated glucose into metabolic products (lactate, glutamate) can be followed dynamically for absolute metabolic rate mapping or detected at steady-state for high-contrast metabolic images of aberrant metabolism in pathologies such as tumors and stroke. The high sensitivity, robust acquisition methods, availability of affordable deuterated substrates and the option for time-efficient, interleaved acquisition of DMI and MRI, combine into a highly robust metabolic imaging method with strong potential to become a dominant MR research tool and a viable clinical imaging modality.