ISMRM22 - Immune System: Friend & Foe

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

Immune System: Friend & Foe

Weekday Course

ORGANIZERS: Elizabeth Hecht, Mary-Louise Greer, Daniel Moses, Christian Federau, Emmanuel Barbier

Thursday, 12 May 2022

ICC Capital Suite 7 & 12

14:45 - 16:45

Moderators:
Immune System I: Susan Shelmerdine

Skill Level: Basic to Advanced

Session Number: Th-03

Session Number: Th-03

Overview
This educational session will focus on the principles and applications of immunotherapy with a focus on body oncology and multiple sclerosis. The role of MRI will be highlighted. Additionally, an update on post-COVID effects in children and adults will be provided.

Target Audience
Pediatric, body, and neuro radiologists and trainees; clinician scientists and M.D.s with an interest in immunotherapies and COVID-19 sequelae.

Educational Objectives
As a result of attending this course, participants should be able to:
- Review basic and advanced immunotherapy strategies for a range of indications;
- Identify pitfalls and challenges in assessing response to immunotherapy in body oncology and multiple sclerosis; and
- Recognize long-term manifestations of COVID-19 in children and adults.

	Immune System I
14:45		Basic Concepts & Emerging Developments in Immunotherapy View the Presentation Yvonne Saenger
15:15		Challenges of Assessing Response to Immunotherapy in Body Cancers View the Presentation Priya Bhosale This presentation will discuss the imaging findings of tumors post treatment and the different response criteria that are used in assessing tumor response.
	Immune System II
15:45		Immunotherapy for Treatment of Multiple Sclerosis & the Role of Myelin-Sensitive MRI Video Unavailable Cornelia Laule Conventional MRI plays a major role in evaluating new multiple sclerosis (MS) immunotherapies. However, proton density, T₁-weighted, T₂-weighted and volumetric imaging have low pathological specificity and poor sensitivity for non-lesional disease, driving the development of new techniques to measure myelin, which is the primary target of damage in MS. Each technique has different strengths and weaknesses with respect to myelin-specificity and myelin-sensitivity. The choice of method ultimately depends on the research or clinical question being asked.
16:15		Post-Infectious Inflammatory Syndromes in the Pediatric Patient View the Presentation Shema Hameed This presentation will include a brief overview of the variety of recognised post-infectious inflammatory disorders in children, and will focus on the novel post COVID-19 entity termed Paediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS) in the UK/EU and Multisystem inflammatory syndrome in children (MIS-C) in North America. The multi-system, multi-modality spectrum of imaging findings will be reviewed, along with a discussion of long-term outcomes from what we know so far.