ISMRM22 - MRI Contrast to Measure Vascular Function

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

MRI Contrast to Measure Vascular Function

Weekend Course

ORGANIZERS: Alan Koretsky, Shin-Lei Peng

Saturday, 07 May 2022

N11 (Breakout B)

13:00 - 17:00

Moderators:
All Sections: Jeremy Collins

Skill Level: Basic to Intermediate

Session Number: WE-12

Session Number: WE-12

Overview
Junior Fellow Observer: Stephan Kaczmarz

This course provides the background physics and methods for vascular imaging acquisition and analysis. Three main methods are included: MR angiography, contrast bolus tracking, and arterial spin labeling and vascular space occupancy. Lastly, the disease that uses all of above is discussed.

Target Audience
Radiologists, scientists, medical physicists, engineers, and clinicians who would like an overview of vascular imaging techniques will gain an update on new developments and knowledge in these field.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the different contrast mechanisms available for vascular image;
- Explain the pros and cons to each vascular imaging approach; and
- Identify which vascular imaging approach is best suited to the application given a specific vascular imaging application.

	Vascular Function: Back to Basics
13:00		MR Angiography: Basics TBD
	Vascular Function: New Horizons in Clinical
13:25		MR Angiography: Translational Potential to Combine High-Resolution MRA with single-vessel BOLD, CBV and CBF-velocity fMRI View the Presentation Xin Yu, David Hike There are two ongoing challenges when specifying vascular function underlying vascular cognitive impairment in patients. One issue is the size of vessels that altered anatomy and function can be detected in the brain. The other issue is the location of the affected vessels to be detected, e.g. gray matter vs. white matter, or cortical vs. subcortical cerebral vasculature. MR Angiography(MRA) provides the key anatomical vasculature measurement when studying cerebrovascular diseases or impaired cerebral blood flow related to vascular dementia. Here, we will discuss the linkage of high-resolution MRA with single-vessel fMRI to characterize vessel-specific oxygenation(BOLD), cerebral volume, and flow changes.
	Vascular Function: Back to Basics
13:50		Dynamic Contrast: Basics View the Presentation Ho-Ling Anthony Liu Dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) MRI are two widely used methods in the clinic to evaluate perfusion and microvasculature of the tissue. They acquire dynamic T2*- and T1-weighted images, respectively, before and after a bolus injection of the Gd-based contrast agent (GBCA). The measured signal time curves can be converted to concentration time curves which are then used to quantify physiological parameters, such as blood flow, blood volume, transit times, vessel permeability, and volume fraction of the extravascular extracellular space. This lecture will cover basic principles, image acquisition, and quantitative analysis of the two MRI methods.
	Vascular Function: New Horizons in Clinical
14:15		Dynamic Contrast: State of Clinical Applications TBD
14:40		Break & Meet the Teachers
	Vascular Function: Back to Basics
15:05		ASL: Basics View the Presentation Hanzhang Lu Arterial spin labeling (ASL) MRI is a non-invasive technique to measure cerebral blood flow (CBF) and other hemodynamic parameters. In 2015, an ASL white paper was published on the clinical implementation of ASL, which largely harmonized the acquisition and processing of ASL MRI in basic science and clinical application. More recently, there are several ongoing efforts that aim to provide further recommendations on the use of ASL MRI. There is also an international initiative to standardize and enable open-source processing of ASL MRI data. This presentation will provide a summary of these latest progress.
	Vascular Function: New Horizons in Clinical
15:30		ASL/VASO: State of Clinical Applications View the Presentation Lirong Yan Vascular imaging has been widely used in clinical routine practice. Arterial spin labeling (ASL) and vascular space occupancy (VASO) are two non-invasive vascular MRI techniques that enable measuring cerebral blood flow (CBF) and cerebral blood volume (CBV), respectively, without the use of exogenous tracers. Given the complete non-invasive profile, ASL and VASO have been demonstrated as useful vascular imaging tools in some selected clinical applications, such as stroke, vascular malformation, tumor, and neurodegenerative diseases, etc. This talk will review the current state of clinical applications using ASL and VASO.
15:55		Applications of MRI Vascular Function to Disease I View the Presentation Chun Yuan MRI contrast agent application has played a key role in vascular disease diagnosis from its early adoption in dynamic MR angiography to recent applications in a wide range of vascular disease: such as atherosclerosis, aneurysm, and vasculitis. Imaging techniques including analysis tools have also advanced to improve data acquisition, quantitation, and analysis.This talk will introduce several contrast agent applications in vascular disease and the technical advancement.
16:20		Applications of MRI Vascular Function to Disease II Video Unavailable Lawrence Latour