ISMRM22 - MRI Diagnostics in the Body: Screening Tool & Quantitative Adoption

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

MRI Diagnostics in the Body: Screening Tool & Quantitative Adoption

Weekend Course

ORGANIZERS: Nandita DeSouza, Scott Reeder, Katja Pinker-Domenig, Masako Kataoka

Sunday, 08 May 2022

ICC Capital Suite 10-11

07:45 - 11:45

Moderators:
MRI for Screening: Technical Considerations: Sunitha Thakur
MRI for Screening: How to Plan Screening Programs: Katja Pinker-Domenig
Quantitative Imaging Biomarkers in Body MRI I: Jessica Winfield
Quantitative Imaging Biomarkers in Body MRI II: Simon Doran

Skill Level: Intermediate to Advanced

Session Number: WE-17

Session Number: WE-17

Overview
The first half of the course will address MRI for screening, using breast screening as an example. Talks will review the challenges in implementing MRI screening and technical development of screening MRI, which aims to increase access to MRI by shortening scan time or reducing the burden of contrast agent administration.

The second half of the course will address use of quantitative biomarkers as clinical tools. The participant will gain understanding of the errors in quantitation and how to handle uncertainty around quantitative measurements and interpret them accordingly. The use multiple quantitative MRI metrics as decision tools will be discussed. A clinical example of a successful quantitative metric, fat fraction, will be illustrated. The challenges of quantitation in the newer newer field of radiomics will be highlighted.

Target Audience
M.D.s and Ph.D.s interested in utilizing MRI for detecting and monitoring early disease as a tool for screening, disease surveillance, and prediction of risk of disease and its outcomes.

M.D.s and Ph.D.s who are developing and using quantitative biomarkers in the clinic.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the errors associated with quantitative metrics and how to handle and interpret them;
- Recall insights into the use of multiple quantitative metrics;
- Recognize the successes and challenges of implementing a quantitative biomarker, including radiomics; and
- Set up MRI-based screening.

	MRI for Screening: Technical Considerations
07:45		Noncontrast Screening Using Diffusion-weighted MRI for Breast Cancer Video Permission Withheld Hee Shin As there are growing interests in risk-based supplemental breast cancer screening and concerns about gadolinium deposition in the brain, diffusion-weighted MR imaging (DW MRI) has emerged as a promising modality for identifying mammographically occult malignancy. Current evidence suggests that DW MRI combined with nonenhanced T1- and T2-weighted sequences provides a higher sensitivity than mammography or mammography combined with ultrasound but lower sensitivity than DCE MRI. Advances in DW MRI acquisition, post-processing, and standardized interpretation have significantly improved DW MRI performance in cancer detection. In this lecture, the potential role of DW MRI as a screening modality will be provided.
08:10		Abbreviated MRI View the Presentation Christiane Kuhl
	MRI for Screening: How to Plan Screening Programs
08:35		How to Plan Conduct Screening Program View the Presentation Elizabeth Morris
09:00		Integration of AI & MRI in Screening/Risk Prediction View the Presentation Almir Bitencourt The use of artificial intelligence (AI) in radiology is rapidly evolving, with many possible applications for different imaging modalities. Breast cancer screening is perhaps the best known and most researched use case. Despite mammography is probably the imaging modality with more data available for breast cancer screening, radiomics and AI have been applied to improve the assessment of breast magnetic resonance imaging (MRI) in different applications, including breast cancer risk prediction, lesion detection and classification. The aim of this presentation is to review the current knowledge and future applications of AI on MRI for breast cancer screening and risk prediction.
09:25		Break & Meet the Teachers
	Quantitative Imaging Biomarkers in Body MRI I
09:50		Handling Uncertainty in Quantitative Biomarker Imaging: Challenges & Solutions View the Presentation Angel Alberich-Bayarri Uncertainty in the quantification of imaging biomarkers from MRI can be minimized by the control of different aspects of the quantification process, based on the principles of metrology science. Both technical and clinical validation are fundamental for the success of the biomarker. Technical validation includes the determination of the accuracy and precision of the measurement. Nevertheless, a biomarker can be not properly adopted in clinical routine if it is not clinically validated. For that, the inclusion of clinical endpoints such as the ones handled in oncology (overall survival, event free survival) is fundamental to demonstrate utility of quantitative imaging.
10:15		Strategies for Assessing Technical Performance of Single & Multiplexed QIBs Video Unavailable Alexander Guimaraes
	Quantitative Imaging Biomarkers in Body MRI II
10:40		Exploiting Quantitative Fat Imaging in the Body View the Presentation Takeshi Yokoo
11:05		Radiomics: Addressing the Quantitative Challenges View the Presentation Laure Fournier, Antoine Decoux, Paul Habert, Armelle Arnoux, Loic Duron