ISMRM22 - Putting Muscle into MRI of Muscle

Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting • 07-12 May 2022 • London, UK

Putting Muscle into MRI of Muscle

Weekend Course

ORGANIZERS: Iman Khodarahmi

Sunday, 08 May 2022

ICC Capital Suite 7 & 12

07:45 - 11:45

Moderators:
MRI Muscle I: Pierre Carlier
MRI Muscle II: Dimitrios Karampinos
MRI Muscle III: Mark Schweitzer
MRI Muscle IV: Christopher Burke

Skill Level: Intermediate to Advanced

Session Number: WE-18

Session Number: WE-18

Overview
Junior Fellow Observer: Stefan Ruschke

This course will review advanced imaging techniques for muscle with an emphasis on high level clinical translation. Topics to be covered include neuromuscular disease and quantitative and qualitative assessment of muscle in health and disease (including neuromuscular disease, metabolic disorders, motor neuron disease and trauma). Principles and applications of quantitative imaging and spectroscopy for muscle will be reviewed and discussed in the context of their application in clinical practice. Exercise physiology and dynamic imaging of muscle, the anatomy and imaging of the myotendinous unit, MR neurography in the context of neuromuscular disease, and whole-body MRI for body composition will also be reviewed and discussed. The speakers in this session will illustrate technical, clinical, and imaging perspectives that will present an integrated approach to muscle imaging.

Target Audience
Radiologists, physicists, engineers, and trainees.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify basic types of neuromuscular diseases and the clinical application of MRI in the management of neuromuscular, metabolic, and motor neuron disease;
- Summarize quantitative imaging techniques and the basic principles of spectroscopy (proton and multinuclear) in the probing muscle tissue;
- Explain the anatomy and physiology of the myotendinous unit in the context of MRI in health and disease; and
- Discuss current and future status of whole-body MRI for body composition, including acquisition techniques and body composition markers.

	MRI Muscle I
07:45		MRI Applications in Neuromuscular Disorders View the Presentation Benjamin Howe
08:10		MRI Neurography in Neuromuscular Disease View the Presentation Shivani Ahlawat
	MRI Muscle II
08:35		Quantitative Muscle Imaging View the Presentation Hermien Kan Quantitative MR imaging is usually slower compared to MR conventional imaging, but has the advantage of being more objective, precise and sensitive to detect changes. In this talk I will highlight a number of quantitative MRI techniques that are commonly used in skeletal muscle, along with their accuracy, sensitivity, reproducibility, and relation to a biological property. Quantitative MR of muscles makes use of range of techniques and as pathology is rarely limited to a single feature, there is a strong added value in combining different MR measurements, where assessments are co-localized based on pathology.
09:00		Proton & Multinuclear Spectroscopy of Muscle View the Presentation Linda Heskamp This lecture introduces the basic principles of MR Spectroscopy at a basic level suitable for clinicians with a specific focus on skeletal muscle. Metabolites detectable with ¹H MRS, ³¹P MRS, ¹³C MRS and ²³NA MRS will be discussed together with the software and hardware requirements.
09:25		Break & Meet the Teachers
	MRI Muscle III
09:50		MRI of Body Composition View the Presentation Danoob Dalili
10:15		Morphologic Imaging of the Myotendinous Unit View the Presentation Jung-Ah Choi In this presentation, the author will familiarize the audience with anatomy and structure of muscle with emphasis on morphologic MR imaging of normal muscle, as well as MRI of pathologic conditions of muscle, including trauma and non-traumatic lesions, including inflammatory myositis, infectious myositis, rhabdomyolysis, atrophy with fatty infiltrations due to congenital or denervation atrophy. After this talk, the audience should be able to diagnose different pathologies of muscle on morphologic MRI.
	MRI Muscle IV
10:40		Exercise Physiology & Dynamic MRI View the Presentation Benjamin Marty Dynamic magnetic resonance spectroscopy (MRS) and imaging (MRI) techniques are perfectly suited to investigate the physiological adaptation of the skeletal muscle during exercise. The consumption and resynthesis of adenosine triphosphate (ATP), which is the principal high-energy phosphate molecule that enables muscle contraction can be precisely followed using dynamic ³¹P MRS. Oxygen delivery and extraction, which limit the rate of ATP resynthesis during aerobic exercise can be estimated from the Fick law, using perfusion MRI coupled with susceptometry and/or deoxy-myoglobin ¹H MRS. All these valuable data can be recorded at once during the same exercise bout using multinuclear interleaved sequences.
	MRI Muscle I
11:05		Case Review with Discussion View the Presentation Darryl Sneag