View Presentation Video

Jonas Frederik Faust^1,2, Peter Speier¹, Axel Joachim Krafft¹, Sunil Patil³, Mark E. Ladd^2,4, and Florian Maier^1
1Siemens Healthcare GmbH, Erlangen, Germany, ²Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany, ³Siemens Medical Solutions USA Inc., Malvern, PA, United States, ⁴German Cancer Research Center (DKFZ), Heidelberg, Germany

Keywords: Interventional Devices, MR-Guided Interventions

Dephased MRI, e.g., used for the delineation of metallic interventional devices, is the reconstruction of images from a shifted k-space and can be achieved by introducing additional “White-Marker” magnetic field gradient moments into the acquisition scheme. A prototype 3D radial sequence was implemented to analyze and compare the artifact of a biopsy needle in a gel phantom for dephased GRE and dephased bSSFP contrast. We found dephased bSSFP to show improved artifact symmetry in comparison with dephased GRE. Undesired signal attributed to fat tissue interfaces in an ex-vivo phantom was successfully suppressed by introducing an altered bSSFP phase cycling.

View Presentation Video

Caiyun Shi^1,2, Jing Cheng¹, Xin Liu¹, Hairong Zheng¹, Yanjie Zhu¹, Dong Liang^1,3, and Haifeng Wang^1
1Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, Shenzhen, China, ²Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, China, Shenzhen, China, ³Research Centre for Medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, China, Shenzhen, China

Keywords: Interventional Devices, Machine Learning/Artificial Intelligence

Susceptibility-based positive contrast MR imaging exhibits excellent efficacy for visualizing the MR compatible metallic devices, by taking advantage of their high magnetic susceptibility. In this work, a model-based deep learning architecture with U-net is developed to realize the 3D susceptibility-based positive contrast MR imaging on real phantom experiments. We train the network on synthetic data to generate positive contrast images from magnetic field maps for localizing the seeds from their surroundings and demonstrate the potential of the deep learning implementation.

Engin Baysoy¹, Gizem Kaleli-Can², Alpay Özcan³, and Chunlei Liu^4
1Department of Electrical Engineering and Computer Sciences, UC Berkeley, BERKELEY, CA, United States, ²Department of Biomedical Engineering, İzmir Demokrasi University, İzmir, Turkey, ³Department of Electrical and Electronics Engineering, Boğaziçi University, İstanbul, Turkey, ⁴Department of Electrical Engineering and Computer Sciences, UC Berkeley, Berkeley, CA, United States

Keywords: Interventional Devices, MR-Guided Interventions, Passive Tracking, Melanin Nanoparticles, MRI devices, interventional MRI

Natural melanin nanoparticles (MNPs) labeled with paramagnetic ions provide a potential MRI contrast enhancing material alternative to current MRI contrast agents due to their biocompatibility, biodegradability, metal, and biomolecule chelation properties. In this study, we investigated T1 shortening effect of Fe³⁺ chelated MNPs solution compared to gadolinium-based contrast agents under 3T MRI. Then, we examined traceability of MNP-Fe³⁺ ions deposited interventional nitinol guidewire in MR scans. Results clearly showed that the coating of Fe³⁺ chelated MNPs over the surface of MRI compatible instruments will increase traceability of interventional devices in MRI. 

View Presentation Video

Kilian A. Dietrich^1,2,3,4, Sebastian Klüter^2,5,6, Jürgen Debus^{2,3,4,5,6,7,8,9,10}, Mark E. Ladd^1,3,9, and Tanja Platt^1,2,4
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany, ³Faculty of Physics, Heidelberg University, Heidelberg, Germany, ⁴Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ⁶Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany, ⁷National Center for Tumor Diseases (NCT), Heidelberg, Germany, ⁸German Cancer Consortium (DKTK), Heidelberg, Germany, ⁹Faculty of Medicine, Heidelberg University, Heidelberg, Germany, ¹⁰Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany

Keywords: Interventional Devices, MR-Guided Interventions, Particle therapy

Electromagnetic field simulations were performed at 1.5T to characterize the imaging capabilities of an RF body coil that is compatible with MR-guided radiotherapy and that can be rotated to achieve a flexible coil to fixed beam orientation. Transmit and receive field characteristics of the RF coil were calculated inside a phantom, and the homogeneity and power efficiency were analyzed for 24 different angles of rotation.

View Presentation Video

Felipe Godinez¹, Özlem Ipek^2,3, Jeffrey Hand^2,3, Fatima Ben Haj⁴, Joseph V Hajnal^2,3, and Shaihan J Malik^2,3
1University of California Davis, Sacramento, CA, United States, ²School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Centre for the Developing Brain, King's College London, London, United Kingdom, ⁴Davis Senior High School, Davis, CA, United States

Keywords: Interventional Devices, Safety

Endovascular interventional devices can heat when used in an MRI system. The heating mechanism can be evaluated using the electric transfer function. In this work we evaluated the TF for a partially inserted guidewire as used in practice, at frequencies corresponding to 0.55T, 1.5T, and 3T. The study revealed that the transfer function varies dramatically with insertion depth for some frequencies and not others.

View Presentation Video

Nandita Saha^1,2, Andre Kuehne³, Jason M. Millward¹, and Thoralf Niendorf^1,4
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²The Charité – Universitätsmedizin, Berlin, Germany, ³MT MedTech Engineering GmbH, Berlin, Germany, ⁴Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Keywords: Interventional Devices, MR-Guided Interventions, Thermal MR

This work proposes the concept of four RF applicators combining SGBT dipole and loop building block antenna array for diagnostic proton (¹H) imaging and thermal intervention at 7.0T, 9.4T and 10.5T. We demonstrated the relationship  between spatial arrangement of the antennas in RF applicator and the SAR profile which further related to temperature rise for targeted thermal intervention of deep-seated brain tumors. This approach of design, simulation, optimization of EM power deposition followed by calculation of the resulting temperature distribution can be adapted as a pre-routine to conduct optimization result for individual patient for further treatment planning.

View Presentation Video

Yunkun Zhao¹ and Xiaoliang Zhang^1
1Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, United States

Keywords: Interventional Devices, MR-Guided Interventions

This study presents a technique of using high permittivity dielectric materials for catheter tracking in interventional endovascular imaging procedures. The design includes a high dielectric material cylinder at the tip of the catheter. Given the small size and limited space of the catheters, it is challenging to implement the current catheter tracking techniques. In the proposed approach, the high permittivity material mounted on tip of the catheter can amplify the local magnetic fields and makes the catheter tip visible. This method doesn’t need any feeding cables and is not sensitive to the frequency shift which makes it easy to implement.

View Presentation Video

KOMLAN PAYNE¹, Yunkun Zhao¹, Leslie Lei Ying¹, and Xiaoliang Zhang^1
1Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States

Keywords: Interventional Devices, Blood vessels

Catheter-based radio frequency (RF) coils for interventional MRI are proposed as a means of obtaining high resolution images with significant advantages over conventional external signal detecting RF coils. A 4-channel catheter array coil was designed to improve the power transmission and SNR using parallel imaging and ultra-sensitive imaging with maximum proximity inside a blood vessel phantom. This design can be scaled to smaller/larger form to fit in tiny/wide vascular structure to provide the required B1 fields and sufficient decoupling among the resonant elements. Numerical simulation was employed to validate the performance and the feasibility of the proposed design.

View Presentation Video

Bridget F Kilbride¹, Teri Moore¹, Alastair J Martin¹, Mark W Wilson¹, and Steven W Hetts^1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Keywords: Interventional Devices, Interventional Devices

Intra-arterial chemotherapy following blood-brain barrier opening (BBBO) can be a highly effective therapeutic delivery mechanism when treating primary and metastatic disease in the brain. Osmotic blood-brain barrier disruption has long been performed under x-ray guidance but has yet to gain clinical traction partially due to outcome variability. MRI is advantageous for its superior soft tissue contrast and real-time perfusion territory validation. We propose a passive microcatheter to provide real-time feedback of catheter positioning during BBBO under MRI guidance. In a phantom, we quantitated susceptibility artifacts at 3T. The catheter showed promise as a new MRI-visible tool to enhance BBBO procedures.

View Presentation Video

James H Holmes^1,2,3, Collin J Buelo^4,5, Ruiqi Geng^4,5, Matthew R Tarasek⁶, Desmond TB Yeo⁶, Christopher L Brace^5,7, Diego Hernando^5,7,8, Aaron Faacks⁵, Jia Xu¹, Francisco Donato Jr.¹, and Shane A Wells^5,9
1Radiology, University of Iowa, Iowa City, IA, United States, ²Biomedical Engineering, University of Iowa, Iowa City, IA, United States, ³Holden Cancer Center, University of Iowa, Iowa City, IA, United States, ⁴Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁶GE Research, Niskayuna, NY, United States, ⁷Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁸Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁹Urology, University of Wisconsin-Madison, Madison, WI, United States

Keywords: Interventional Devices, MR-Guided Interventions

In this work we report initial results evaluating the imaging artifacts associated with different candidate materials for use in needle-based interventions. The impact of each material was assessed using MRT and DWI ADC as well as compared with local B_o field maps.

View Presentation Video

Nandita Saha^1,2, Rita Schmidt³, and Thoralf Niendorf^1,4
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany, ²The Charité – Universitätsmedizin, Berlin, Germany, ³Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, ⁴Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Keywords: Interventional Devices, RF Arrays & Systems, Metamaterial surface

  This work proposes the feasibility of passive metasurface (MS) to enhance the RF power deposition for  Thermal Magnetic Resonance based treatment of brain tumors.  An 8 channel hybrid RF applicator combining dipole antenna and passive MS is designed and evaluated at 7.0 T (300 MHz), 9.4 T (400 MHz) and 10.5 T (450 MHz). MS with metal strips  inside waterbolus was designed which generates expected resonant modes of the thermal intervention frequency. The result demonstrated use of passive metamaterial surface in RF applicator enhances the RF power deposition inside target volume for targeted RF heating of deep seated brain tumor.

View Presentation Video

Wang Nianhua ¹, Yao wang¹, and Jiang Xinqing^1
1Guangzhou First People’s Hospital, Guangzhou, China

Keywords: Multimodal, Molecular Imaging, MRI Near Infrared Ray

Photodynamic therapy is a non-invasive and controllable modality with potential as a novel cancer treatment strategy. However, the ROS production efficiency of PDT is restricted to hydrophobic characteristics and aggregation caused quenching of PSs. Herein, we designed a ROS self-activatable polymer (PTKPa) to suppress photosensitizers ACQ and elevate ROS production capacity. This platform shows therapeutic outcomes in both cells and orthotopic mouse model, which can significantly elevate the intracellular ROS level upon 660nm laser irradiation, induce immunogenic cell death (ICD) to activate antitumor immunity. This work provides a general strategy enhancing tumor photodynamic therapeutic effects. 

View Presentation Video

Thomas Lilieholm¹, David A Woodrum², Walter F Block^1,3,4, and Erica M Knavel Koepsel^3
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, Mayo Clinic, Rochester, MN, United States, ³Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Keywords: Interventional Devices, Visualization

Utilizing MR guidance for minimally-invasive prostate interventions is known to improve the precision and accuracy of the procedure. Previous work has been done to develop and propose an integrated platform for conveniently providing this image guidance to clinicians for use with transperineal prostate interventions. Since then, the proposed methodology has been applied, in a limited capacity, to assist in an in-vivo prostate biopsy.  It was found that the trajectory computation component of the platform was able to accurately guide needle placement to the clinician-selected anatomical regions with little need for correction.

Xinrui Pang¹, Ruili Wei¹, Ye Wang¹, Fangrong Liang¹, and Ruimeng Yang^1
1Department of Radiology, Guangzhou First People’s Hospital, GuangZhou, China

Keywords: Whole Body, Cancer, Immunity therapy

Low immune infiltrates severely hinder cancer immunotherapy. Hence, we developed a manganese-phenolic networks platform (TMPD) The TMPD was based on doxorubicin (DOX) loaded PEG-PLGA nanoparticles and further coated with manganese (Mn)-tannic acid (TA) networks. Mechanistically, DOX could kill cancer cells while Mn²⁺ could significantly increase the activity of STING pathway related protein to amplify the STING signal and has the function of MRI T₁ imaging. The nanoplatform could promote the presentation of tumor antigens and activate a robust innate and adaptive immunity, providing reference for the application of molecular imaging in tumor diagnosis and treatment.

View Presentation Video

Nadya Pyatigorskaya¹, Yoann Sclover², Aurelie Kas², Lydia Yahia-Cherif¹, and Melika Sahli Amor ^2
1ICM, Paris, France, ²APHP, Pitié Salpêtrière, Paris, France

Keywords: PET/MR, Head & Neck/ENT, ENT, head and neck, PET/MRI, lymph nodes

The aim of our study was to analyze the imaging characteristics of lymph nodes on pre-operative PET-MRI to find the predictors of recurrence or progression.273 patients with ATD cancer who underwent PET-MRI were included. Lymph node PET/MR analysis has shown that the strongest predictors of the recurrence were lymph node enhancement and SUVmax for the controlateral nodes and enhancement, SUVmax node shape for the homolateral nodes. In conclusion, PET-MRI can be an interesting tool in the pre-therapeutic assessment of primary tumors of the ADT with lymph node extension, particularly in the identification of predictive characteristics of recurrence or progression.

View Presentation Video

Qiaoyan Chen^1,2, Zhonghua Kuang^1,2, Yongfeng Yang^1,2, Changjun Tie^3,4,5, Xiaoliang Zhang⁶, Xin Liu^1,2, Hairong Zheng^1,2, and Ye Li^1,2
1Paul C. Lauterbur Imaging Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China, ³Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China, ⁴University of Chinese Academy of Sciences, Beijing, China, ⁵Peng Cheng Laboratory, Shenzhen, China, ⁶Department of Biomedical Engineering, State University of New York at Buffalo, New York, NY, United States

Keywords: PET/MR, PET/MR

Simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) shows advantages in clinical and research applications for human brain. In this work, MRI compatibility of a brain PET insert integrated with a quadrature birdcage transmit /47-channel receiver head coil assembly was studied. The results of RF field (B₁⁺) distribution, signal-to-noise ratio (SNR) and static field inhomogeneity (ΔB₀) show MRI compatibility of the brain PET insert. Simultaneous PET/MRI was implemented, which demonstrated a high performance of the brain PET/MRI system.

View Presentation Video

Leo Marecki¹, Suyog Pol¹, Robert Zivadinov^1,2, and Ferdinand Schweser^1,2
1Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

Keywords: PET/MR, Preclinical

We developed a retrofitted alignment apparatus that attaches to the MRI’s motor-driven automated positioning system and enables simultaneous preclinical PET/MRI at 9.4T with a stand-alone microPET ring. The system leverages 3D printing technology to achieve stable alignment between the two modalities, consistent placement of animals, and rapid reconfiguration between PET-MRI and MRI-only experiments. Thereby addressing the shortcomings of other retrofitted designs and proving simultaneous PET-MRI capabilities at a reduced cost.

View Presentation Video

Harris Bidaman¹, Katie Dinelle¹, Reggie Taylor^2,3, and Lauri Tuominen^2,4
1Brain Imaging Centre, Royal Ottawa Mental Health Centre, Ottawa, ON, Canada, ²University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada, ³Department of Physics, Carleton University, Ottawa, ON, Canada, ⁴Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada

Keywords: PET/MR, Brain, Coil

We evaluate MRI and PET performance of the novel Siemens 32 channel head coil for the Siemens Biograph mMR. Results are compared to the system standard 12 channel coil. MRI performance (SNR) was improved with the 32 channel coil. PET image uniformity was not impacted. ROI analysis of the PET data indicated a 5% underestimation of activity concentration in the 32 channel coil, however this difference was mitigated by the use of an image derived reference region. Any small differences in PET performance introduced by the 32 channel coil are far outweighed by the superior MRI performance of this coil.

View Presentation Video

Elise Noelle Woodward¹, Heeseung Lim^2,3, Ramanpreet Kaur Sembhi¹, Matthew S Fox^1,2, and Alexei Ouriadov^1,4
1Physics and Astronomy, Western University, London, ON, Canada, ²Lawson Health Research Institute, London, ON, Canada, ³Siemens Healthcare Limited, London, ON, Canada, ⁴2Lawson Health Research Institute, London, ON, Canada

Keywords: RF Arrays & Systems, Hyperpolarized MR (Gas)

This study aims to present two birdcage radiofrequency (RF) coils for the use of simultaneous hyperpolarized Xenon-129 (¹²⁹Xe) MRI and ¹⁵O₂ PET imaging for brain perfusion measurements. Coils were designed for use with a 2.89T Siemens scanner, or 34.05MHz, one using a low pass filter design, and the other a high pass filter design.

View Presentation Video

Petra Albertova^1,2, Maximilian Gram^1,2, Martin Blaimer³, Magnus Schindelhütte⁴, Thomas Kampf⁴, Peter Michael Jakob², and Peter Nordbeck^1,5
1Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ²Experimental Physics 5, University of Würzburg, Würzburg, Germany, ³Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany, ⁴Department of Diagnostic and Interventional Neuroradiology, University Hospital Würzburg, Würzburg, Germany, ⁵Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany

Keywords: Bioeffects & Magnetic Fields, Pulse Sequence Design, spin-lock

With spin-locking, the resonance of the spin system can be shifted adjustably to the low frequency range for detection of biomagnetic field oscillations. In this study, we demonstrate that spin-locking is also sensitive to peak-like magnetic field fluctuations with broader spectral width. Simulations and measurements demonstrate that, in addition to the application of imaging neural oscillations, the spatially resolved detection of biomagnetic peaks is possible. Initial results show a high agreement between simulations and experiments and mark a first step towards spin-lock based diagnostics of biomagnetic activity, e.g. imaging of the cardiac conduction system.