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Michela Fratini^1,2, Isabel San Martín Molina³, Manfred Burghammer⁴, Tilman Grünewald^4,5, Raimo A. Salo³, Omar Narvaez³, Maria Guidi⁶, Federico Giove⁶, Manisha Aggarwal⁷, Jussi Tohka³, Alejandra Sierra³, and Gaetano Campi^8
1Nanotec, CNR, Roma, Italy, ²IRCSS Santa Lucia Foundation, Roma, Italy, ³University of Eastern Finland,, Kuopio, Finland, ⁴European Synchrotron Radiation Facility, Grenoble, France, ⁵Aix-Marseille Université, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France, ⁶Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Rome, Italy, ⁷Russell H. Morgan Department of Radiology and Radiological Science, , John Hopkins University School of Medicine, Baltimore, MD, United States, ⁸Institute of Crystallography, CNR, Rome, Italy

Keywords: Multimodal, Tissue Characterization, x ray scanning diffraction

We have combined high-resolution structural imaging techniques, such as scanning micro-X-ray diffraction (SμXRD), DTI and histology to study the myeloarchitecture in both healthy and pathological rat brains. For the latter, we focused on an animal model of mild traumatic brain injury (mTBI) that is the most common form of acquired brain injury caused by an external force into the brain. We have performed a quantitative morphometrical analysis of myelin, mapping its relevant morphological and topological parameters (period, orientation, and  integrated intensity fluctuation) to assess tissue microstructural damage 35 days after mTBI and sham-operation

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Renesmee Kuo¹, John Pauly¹, Fraser Robb², Shreyas Vasanawala¹, and Greig Scott^1
1Stanford University, Stanford, CA, United States, ²GE HealthCare, Aurora, OH, United States

Keywords: Hybrid & Novel Systems Technology, Image Reconstruction

Non-contact synchronization MRI with heart motion is still an open challenge. Inaccurate cardiac gating often complicates image reconstruction and leads to poor or non-diagnostic images. Continuous wave doppler radar is a non-contact, noninvasive novel systems technology that could monitor cardiac motions without distortion from the MRI electromagnetic environment while offering an alternative to state-of-the-art (ECG) triggering.

Kangjian Huang¹, Congcong Liu¹, Ye Li¹, Yanjie Zhu¹, Hairong Zheng¹, Dong Liang ¹, and Haifeng Wang^1
1Shenzhen Institute of Advanced Technology，Chinese Academy of Sciences, shenzhen, China

Keywords: Hybrid & Novel Systems Technology, Hybrid & Novel Systems Technology

Because of the imaging coding mode of Magnetic particle imaging (MPI), the drive-field signal directly couples into the receiving coil and covers the magnetic particle signal, which one aims to detect. Therefore, some method is needed to remove the drive-field signal and retain the magnetic particle signal. One of the methods is to use a passive band-stop filter to filter the excitation signal, but the general passive band-reject filter has a large stopband, which filters part of the magnetic particle signal while filtering the drive-field signal. In this study, we design an active twin-T notch filter with narrow stopband, which better restore the magnetic particle signal and improve the signal-to-noise in MPI.

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J. Coupling¹, E. Current¹, and Line SP. Litting^1
1Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Keywords: Hybrid & Novel Systems Technology, New Devices

The topic of this contribution is how artificial intelligence (AI) can be used to engineer future magnetic resonance imaging (MRI) machines and components. MRI machines are vital tools in the medical field, used for everything from diagnosing injuries to detecting cancer. However, they are also extremely complex devices, made up of many different parts that must work together seamlessly.

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Vitaliy Atamaniuk¹, Jun Chen ², Kevin Glaser², Andrii Pozaruk¹, Marzanna Obrzut³, Bogdan Obrzut⁴, Wojciech Domka⁵, Krzysztof Gutkowski⁶, Richard L Ehman², and Marian Cholewa^1
1Department of Biophysics, Institute of Physics, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland, ²Department of Radiology, Mayo Clinic, Rochester, MN, United States, ³Center for Diagnostic Medical Sonography, Rzeszow, Poland, ⁴Department of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland, ⁵Department of Otorhinolaryngology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland, ⁶Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland

Keywords: New Devices, Elastography

A specialized driver was developed to enable magnetic resonance elastography of the parotid and other salivary glands using high shear wave frequencies to provide improved spatial resolution and optimized ergonomics. The performance of this new device was tested in volunteer studies. Preliminary results showed that suitable shear wave illumination of the parotid gland is possible at frequencies as high as 120 Hz and that high-frequency shear wave MR elastography of the parotid gland is feasible.

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Brett Setera^1,2, Aristos Christou², and Natalia Gudino^1
1Laboratory of Functional and Molecular Imaging, National Institutes of Health, Bethesda, MD, United States, ²Department of Materials Science & Engineering, University of Maryland, College Park, MD, United States

Keywords: New Devices, New Devices, Radiofrequency Technology

We present a method for monitoring multiple GaN HEMT device signals at different orientations with B₀ during RF switching to determine possible magnetic field impacts on device performance and assist the development of an optimized GaN based device for on-coil amplification.  Reduction in output current with increased magnetic field strength were not detected and device orientation did not impact signal amplitude.     

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Jacob Patrick Berardinelli¹, Julia Kofler², Jinghang Li³, Owen Flaugh³, Nadim Farhat³, Tales Santini³, Andrea Sajewski³, Noah Schweitzer³, Joseph Mettenburg^2,3, Milos Ikonomovic², Howard J. Aizenstein³, and Tamer S. Ibrahim^3
1Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²UPMC, Pittsburgh, PA, United States, ³University of Pittsburgh, Pittsburgh, PA, United States

Keywords: New Devices, Ex-Vivo Applications

The ability to continuously prototype and 3D print new containers as well as using an improved transmit coil has led to major improvements in ex-vivo image quality. This has also allowed for a more automated registration process of the MR images to the gross anatomy

 

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Yosef Al-Abasse¹, Tova Roman Rung¹, Peter Larsson¹, Dan Josefsson¹, Lena Lundkvist², Kristina Redelius², Kristina Hultman², Maria Nilsson², Jan Rzepecki², and Peter Lundberg^1,3
1Department of Health, Medicine and Care, Linköping University, Linköping, Sweden, ²Department of Oncology, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, ³Center for Medical Imaging and Visualization (CMIV), Linköping University, Linköping, Sweden

Keywords: Multimodal, Radiotherapy, Synthetic CT, T2-w, software

Conventional coils for dose planning purposes cannot be placed on the patient as the outer body contour then will be deformed. Coils are therefore placed on a special holder which creates a distance between coil and patient, but this leads to less SNR. The blanket-coils are significantly lighter and can be placed directly on the patient. Three similarity comparison methods were used here, Hausdorff distance, Dice similarity coefficient (DSC) and Surface DSC.  Eight of eleven comparisons were within 4 mm difference for Hausdorff distance; Surface DSC was >99%, at a 3 mm tolerance, and DSC >98.5%. 

 

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Marc Azagra¹, Alejandro Portela¹, Hetal Patel², Dian Weerakonda², Jose Yeste¹, Alba Herrero-Gómez¹, Matthew Fallon², Megdouda Benamara³, Marc Dubois³, Tryfon Antonakakis³, Javier Ramon¹, and Irene Marco-Rius^1
1Institute for Bioengineering of Catalonia, Barcelona, Spain, ²Oxford Instruments, Abingdon, United Kingdom, ³Multiwave Imaging, Marseille, France

Keywords: New Devices, Hyperpolarized MR (Non-Gas), Molecular Imaging

A benchtop NMR spectrometer has been designed and optimized to monitor real-time metabolism of 3D tissue engineered on microfluidic platforms using hyperpolarization by dynamic nuclear polarisation. We show the design process, which included the modification of a commercial benchtop NMR spectrometer, the design and fabrication of a microfluidic platform for a reliable injection of a hyperpolarized substrate and a constant delivery and renewal of the cell media and its integration with a RF coil for transmit/receive, and the design and fabrication of a sample carrier. We also present our preliminary NMR data using this system.

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Lluís Mangas-Florencio¹, Alba Herrero-Gómez¹, Marc Azagra¹, James Ellis¹, and Irene Marco-Rius^1
1Institute for Bioengineering of Catalonia, Barcelona, Spain

Keywords: New Devices, Cancer, Metabolism

Bioreactor platforms have been used in HP-NMR applications to analyze cellular metabolism in real-time, however they require complex set-ups and automated controlled systems, limiting their use. We present a system that overcomes these limitations consisting of a 3D printed platform, an NMR compatible 3D cell model and a recirculation circuit for single-shot and longitudinal hyperpolarization-enhanced NMR experiments. The platform presents no signal interference, a media system for biological support, and a straightforward and simplified manufacturing and assembly process. As a proof-of-concept, we present preliminary metabolic data of a 3D HeLa cell model analyzed with our bioreactor. 

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Christoph Michael Schildknecht¹, Russell L Lagore², Matt Waks², Gregor Adriany², and Klaas Paul Pruessmann^1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zürich, Switzerland, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Keywords: New Devices, New Devices

An in-bore PIN diode driver with eight output channels is presented here. The driver is based on a single-chip solution making the implementation simple and of high performance. The rise and fall times of the driver's output are in the single-digit nanosecond range with a peak output current of up to 5.7A per channel. Triggering the driver can be done either with an optical or electrical signal. The driver was tested on the bench and in-bore of a 10.5T MR scanner.

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Marc Dubois¹, Amira Trabelsi^1,2,3, Tania Vergara Gomez^1,2,3, Pierre Jomin³, Djamel Berrahou¹, David Bendahan^2,4, Frank Kober^2,4, Virginie Callot^2,4, Stefan Enoch³, and Redha Abdeddaim^3
1Multiwave Imaging, Marseille, France, ²Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ³Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France, ⁴APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France

Keywords: New Devices, Spinal Cord, Metamaterial, Metasurface

Spine imaging is usually conducted at 3T given the need of high spatial resolution. Unfortunately, the lumbar and thoracic spine regions of interest will lie in areas of weak transmit efficiency. Recent studies showed that high permittivity ceramic blocks can improve image quality. Here we present a new approach based on ultra-thin, lightweight, flexible metasurface pads yielding improved efficiency and homogeneity of the B₁⁺ field along the spine in clinical 3T MRI settings. Our design offers seamless integration to regular equipment leading to more efficient and safer spine imaging protocols.

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Jean-Lynce Gnanago¹, Sophie Calvet², Tony Gerges¹, Valernst Gilmus¹, Camila Pereira Sousa¹, Michel Cabrera¹, Julien Falk², and Simon Auguste Lambert^1
1Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, Ecole Centrale de Lyon, CNRS, Ampère UMR5005, Villeurbanne, France, Lyon, France, ²MeLis, CNRS UMR 5284-INSERM U1314-Université Claude Bernard Lyon 1 Institut NeuroMyoGène, Lyon, France, Lyon, France

Keywords: New Devices, Animals

Thanks to their accessibility for experimental manipulations, their availability and their low cost, chick embryos have been used as animal models for developmental biology for long. In these applications, non-invasive 3D imaging of the embryos is needed to monitor the embryos development. Morphological characterization of ex-ovo chick embryo generally require tissue fixing which can alter MR characterizations. In this work, we use our MR-Bioreactor to perform a high resolution morphological characterization of a chick embryo maintained in living conditions.

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Seyedamin Hashemi¹, Kezia Sharon Christopher¹, Sri Kirthi Kandala¹, Kwanjoon Song², Benjamin Bartelle¹, and Sung-Min Sohn^1
1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States, ²Department of Biomedical engineering, Yonsei University, Wonju, Korea, Republic of

Keywords: New Devices, RF Arrays & Systems, Invisible Dielectric pad, Silicon Carbide, SNR enhancement

We propose a stretchable, flexible, and MRI invisible dielectric pad to enhance the quality of acquired MR images. A silicon-based elastomer is mixed with Silicon Carbide (SiC) to develop this proposed dielectric pad. Preclinical in-vivo imaging of a mouse head was conducted at 9.4T to validate the performance of the dielectric pad. 2.54% (in dB) increase in the central SNR of the brain was observed after using the dielectric pad and peripheral brain locations have shown improved contrast. The flexible and stretchable dielectric pad could be used as a substitute for conventional dielectric pads, especially in irregular sample shapes.

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Shouquan Yao¹, Juncheng Xu¹, Yiqiao Song², Ming Shen¹, Bingwen Hu¹, and Yu Jiang^1
1Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China, ²Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Keywords: New Devices, New Devices, Probe

This work demonstrated a broadband NMR probe with a bandwidth of 10-100 MHz. Based on transmission-line structure, broadband transmission was achieved. As for broadband reception, high-speed active T/R switches and low-noise differential amplifiers were used for high-sensitivity RF reception. The SNR of FID signal detected by broadband probe was 74% of that of conventional resonance probe, which means the feasibility of the broadband NMR transmission-line probe was verified.

Rajesh Harsh¹, Dharmesh Verma¹, Aparna Gunvant Raut¹, and Mahadev Kashinath Dipnaik^1
1Medical Systems Division, S.A.M.E.E.R. Mumbai, Mumbai, India

Keywords: New Devices, Spectroscopy, System -on-chip,MIMO Based smart MRI Spectrometer

The increasing complexity of modern MRI hardware design makes system challenging. MRI systems equipped with multi-channel exciter and multi-channel data-acquisition modules, particularly high-channel-counts often requires a huge cost. This abstract summaries the design and development of a low cost, small form factor, system on chip approach to realize a complete 1.5 T MRI spectrometer on a small chip of 28 nanometer fabric. The developed system executes parallel image processing algorithms and compatible instrumentation for accurate spatial and temporal requirements.

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Martin D Holland¹, Seth N Lee², and Harrison D Kim^2
1Interdisciplinary Engineering, University of Alabama at Birmingham, Birmingham, AL, United States, ²Radiology, University of Alabama at Birmingham, Birmingham, AL, United States

Keywords: New Devices, New Devices, Syringe pump, MRI Compatibility, 3D Printing

Delivering a contrast (or therapeutic) agent to a subject inside an MRI bore requires an expensive electronically programmed syringe pump and a long tube filled with the agent. We developed an inexpensive 3D-printed MRI-compatible syringe pump that can be used inside an MRI bore. This syringe pump yields a highly reproducible infusion rate, which can be readily adjusted using gears with different gear ratios.

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Seung-Kyun Lee^1
1GE Global Research, Niskayuna, NY, United States

Keywords: Magnets (B0), Magnets (B0), magnetic damping

The motion of a conductive object is profoundly affected by the presence of a strong magnetic field. A conductive loop falling inside an MRI magnet can serve as an analytically solvable model to explore magnetic damping. We present a pair of magneto-mechanical coupled equations to describe its motion and verify their solution with experimental data. A simple formula for the loop's falling time was obtained, which indicates that magnetic damping is proportional to B₀².

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Sefa Karaca^1,2,3, Damla Alptekin Soydan¹, Emine Ulku Saritas^2,3, and Can Barış Top^1
1Aselsan Research Center, ASELSAN A.Ş., Ankara, Turkey, ²Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey, ³National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey

Keywords: Hybrid & Novel Systems Technology, Low-Field MRI, Magnetic Particle Imaging

Magnetic particle imaging (MPI) is a novel technique that images background-free spatial distribution of magnetic nanoparticles inside the body. The lack of signal from the background tissue provides high sensitivity to MPI. However, anatomical information is also required in many applications. Here, we present an open-bore hybrid preclinical MPI-MRI system, in which the coils can be utilized interchangeably between MPI and MRI data acquisitions. We analyze the imaging performance for both modalities using a simulation model based on our in-house prototype MPI system that can generate 0.5 T/m selection field gradients for MPI and 50 mT B₀ for low-field MRI.