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Jiahui Li¹, Nana K. Owusu¹, Kevin J. Glaser¹, Yi Sui¹, Douglas A. Simonetto², Armando Manduca¹, Sudhakar K. Venkatesh¹, Vijay H. Shah², Richard L. Ehman¹, and Meng Yin^1
1Radiology, Mayo Clinic, Rochester, MN, United States, ²Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

Keywords: Digestive, Digestive

We performed dual-frequency dual-driver abdominal MR Elastography (MRE) on 11 patients with alcoholic hepatitis (AH), and 6 healthy volunteers without known histories of chronic alcohol consumption. Two flexible drivers were placed over the anterior abdominal wall to deliver sufficient shear wave propagation in multiple abdominal organs at two different mechanical frequencies. The liver stiffness (LS) and spleen stiffness (SS) calculated from MRE at 60Hz, and pancreas stiffness derived from 30Hz, all significantly increased in patients with AH, compared with controls. This pilot study indicates the feasibility of dual-frequency dual-driver abdominal MRE to assess the alcoholic impact on multiple organs.

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Robin van Eenige¹, Aashley S.D. Sardjoe Mishre¹, Maaike E. Straat¹, Borja M. Martinez-Tellez¹, Mariëtte R. Boon¹, Oleh Dzyubachyk¹, Andrew G. Webb¹, Patrick C.N. Rensen¹, and Hermien E. Kan^1
1Leiden University Medical Center, Leiden, Netherlands

Keywords: Endocrine, Fat, Supraclavicular brown adipose tissue

Brown adipose tissue (BAT) is considered a therapeutic target in cardiometabolic health for its capacity to combust triglyceride-derived fatty acids into heat. Previous MRI studies consistently reported reductions in fat fraction (FF) in supraclavicular BAT (scBAT) after cold exposure. However, there is limited research on the validity of this outcome against thermoneutral conditions. We compared scBAT FF dynamics and thermal perception scores between mild-cold and thermoneutrality. Cold exposure decreased scBAT ΔFF (-0.73±0.19%), accompanied with colder thermal perceptions during cooling. At thermoneutrality, two out of three participants also showed a scBAT ΔFF decrease (-0.39±0.06%), yet normal thermal perceptions were reported. 

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Uma Sharma¹, Deepti Upadhyay¹, Prasenjit Das ², and Govind K Makharia^3
1Department of Nuclear Magnetic Resonance, All India Institute of Medical Sciences, New Delhi, NEW DELHI, India, ²Department of Pathology, All India Institute of Medical Sciences, New Delhi, NEW DELHI, India, ³Department of Gastroenterology & Human Nutrition, All India Institute of Medical Sciences, New Delhi, NEW DELHI, India

Keywords: Digestive, Body, Celiac disease, Metabolomics, First Degree Relative Celiac Disease, Biomarker, Pathophysiology, NMR Spectroscopy

The present study demonstrated distinct metabolic features of intestinal mucosa biopsies in first-degree relatives (FDRs) of patients with celiac disease (CeD) patients and disease controls (DC) using proton NMR spectroscopy. FDRs had significantly lower levels of proline and allantoin while higher levels of 7 metabolites compared to CeD patients. The results showed a higher concentration of glucose, fumarate, tyrosine, and formate in the FDRs as compared to CeD and DC indicating altered energy metabolism and gut microbiome of FDRs. The obtained results may provide insight into the underlying mechanism involved in the pathophysiology of CeD patients.

Huanhuan Zheng¹, Hailong Zhang¹, Yan Zhu¹, Xiaolei Wei¹, Song Liu¹, and Wei Ren^2
1Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China, ²The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China

Keywords: Digestive, fMRI

To confirm a quantitative imaging predictor for evaluation of early treatment response and prognosis to definitive chemoradiotherapy (dCRT) in patients with esophageal squamous cell carcinoma , using BOLD MR images. R2* values were obtained pre- and  post-dCRT in 28 patients  using BOLD MR. Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare differences of R2*-related parameters between CR and non-CR groups. Diagnostic performance of parameters in predicting response was tested with receiver operating characteristic curve analysis. 3-years overall survival (OS) was evaluated using by Kaplan Meier curve, log rank test, and Cox proportional hazards regression analysis.

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Jing Li¹, Hongkun Yin², Jinxia Guo³, and Jinrong Qu^4
1Radiology, the Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou, China, ²Institute of Advanced Research, Infervision Medical Technology Co., Ltd, Beijing, China, ³GE Healthcare, MR Research China, Beijing, Beijing, China, ⁴the Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou, China

Keywords: Digestive, Radiomics, Gastric cancer; Computed tomography, X-rayed; Neoadjuvant chemotherapy

To compare and combine CT and multi-parametric MRI (mp-MRI) radiomics for early prediction of pathologic response to neoadjuvant chemotherapy (NAC) in locally advanced gastric cancer (LAGC). The CT radiomics model, mp-MRI radiomics model and the combined nomogram were all associated with pathologic response. The multi-modal nomogram containing both CT and MRI radiomics scores exhibited added predictive ability and was linked to patients’ outcome. The CT and MRI radiomics model exhibited equivalent capability. This study proposed a multi-modal radiomics nomogram by incroperating concurrent CT and MRI images, which presents favorable efficacy in predicting treatment response to NAC in LAGC.

Shivanand Pudakalakatti¹, Mark Titus², Imad Shureiqi³, Xiangsheng Zuo⁴, and Pratip Bhattacharya^1
1Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ³University of Michigan, Ann Arbor, MI, United States, ⁴Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States

Keywords: Digestive, Hyperpolarized MR (Non-Gas), 13C Pyruvate, Metabolomics

Peroxisome proliferator-activated receptor delta (PPARD) is a ligand-dependent nuclear transcription factor that regulates a multiplicity of pathophysiological processes vital to cell metabolism. Recent discovery of PPARD overexpressed in villin-positive gastric progenitor cells, demonstrated spontaneous development of large, invasive gastric tumors as the mice aged. These unique animal models allowed us to address the knowledge gap of PPARD-regulated downstream metabolic changes and determine the significance of changes in gastric tumorigenesis by hyperpolarized MRI, NMR spectroscopy and LC-MS. Unlike many cancer systems, we found  these gastric cancer tumors are not primarily dependent on aerobic glycolysis but on  fatty acid oxidation for energy.

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Wei-Yue Xu¹, Qiong Li¹, Ya-Jun Hou¹, Yi-Cheng Hsu², Dominik Nickel³, Yu-Dong Zhang¹, and Xi-Sheng Liu^1
1Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, ³MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Keywords: Contrast Mechanisms, Contrast Mechanisms, deep learning-accelerated T2WI

T2-weighted imaging (T2WI) is an indispensable sequence of gastric magnetic resonance imaging (MRI) for tumor assessment. This study compared the deep learning-accelerated T2WI sequence (DL-T2WI) with BLADE T2WI in image quality assessment and tumor invasion evaluation of gastric cancer (GC). It revealed that DL-T2WI, acquired within a single-breath-hold, performed better than BLADE T2WI in terms of image quality for both quantitative and qualitative analyses. Furthermore, DL-T2WI images displayed comparable accuracy to BLADE T2WI images for serous invasion evaluation. The study suggests that DL-T2WI might be superior to BLADE T2WI for GC.

Yigang Pei¹, Yu Bai¹, Weiyin Vivian Liu², Wenguang Liu¹, and Wenzheng Li^1
1Xiangya Hospital of the Central South University, China, China, ²GE Healthcare, MR Research China, Beijing, China, China

Keywords: Pancreas, Diffusion/other diffusion imaging techniques

DWI is essential in clinical diagnosis of pancreas. Image quality highly influence ADC measurements. Pancreases in abdomen easily suffers from artifact induced by abdominal and chest respiratory motion. A new diffusion-weighted imaging (DWI) sequence was explored to better delineate pancreas in our previous study (named FOCUS-MUSE DWI). In this study, we compared the clinical utility of FOCUS-MUSE DWI, MUSE DWI, FOCUS DWI and SS DWI using four different breathing schemes (RT, NT, BH and FB) for the repeatability of apparent diffusion coefficient (ADC) measurements and image quality. Our results suggested that RT‑DWI provided the best ADC reproducibility and image quality among four breathing schemes on 3.0 T MRI, making it as the recommended protocol for clinical DWI of the pancreas.

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Lanbin Huang¹, Jinglian Zhong², Liping Liao¹, Yingying Huang¹, Zeping Liu³, Qingchun Li¹, Qiceng Ruan¹, Mingxia Tan¹, Mengzhu Wang⁴, Shasha Liao⁵, Zehe Huang¹, and Song Chen^1
1Department of Radiology, The First People's Hospital of QinZhou, Qinzhou, China, ²Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, ³School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, ⁴MR Scientific Marketing, Siemens Healthineers Ltd, Guangzhou, China, ⁵Department of Clinical Pharmacy, Maternity and Child Health care of Guangxi Zhuang Autonomous Region, Nanning, China

Keywords: Digestive, Biliary, MRCP

To compare the image quality of NATIVE-TrueFISP and 3D-SPACE in the MRCP of patients with ascites at 3T scanner. 5 patients with ascites and another 5 patients without underwent conventional upper abdominal MRI and MRCP with two kinds of sequences: NATIVE-TrueFISP and 3D-SPACE. The image quality of the two MRCP methods were independently assessed by two readers. Image quality of 3D-SPACE was superior to TrueFISP in patients without ascites while the TrueFISP sequence achieved better duct visualization in patients with ascites. Native TrueFISP can be used as an optional fast imaging sequence for MRCP of patients with ascites.

Liyun Zheng^1,2,3, Chun Yang^1,2, Yongming Dai⁴, and Mengsu Zeng^1,2
1Shanghai Institute of Medical Imaging, Shanghai, China, ²Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, ³Shenzhen United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China, ⁴MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China

Keywords: High-Field MRI, Pancreas

Despite the growing clinical acceptability of magnetic resonance imaging (MRI) evaluation, continued efforts are required to increase the resolution and robustness of pancreatic imaging. The feasibility of pancreatic MRI at 5T was studied in this study, which used a brand-new 5T MR scanner. 5T pancreatic MRI exhibited greater signal-to-noise ratio (SNR) and sufficient image quality as compared to the 3T examination. Diffusion-weighted imaging (DWI) at 5T was sufficient for measuring the longitudinal pancreatic apparent diffusion coefficient (ADC). As a result, pancreatic MRI at 5T may be effective for diagnosing and managing pancreatic diseases.

Jianguo Zhu¹, Liangqiang Mao¹, Yan Li¹, Weiqiang Dou², and Dmytro Pylypenko^2
1Radiology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²MR Research China, GE Healthcare, Beijing, China

Keywords: Digestive, Diffusion/other diffusion imaging techniques

In summary, our findings suggested that the combination of IVIM and DCE-MRI can be used to accurately stage CD lesions activity. However, we must acknowledge that further investigation area is warranted to validate this preliminary finding.

Yan Wang¹, Jingyun Cheng¹, Weiyin Vivian Liu², and Yunfei Zha^1
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China, ²MR Research, GE Healthcare, Beijing, China

Keywords: Digestive, Image Reconstruction

Higher resolution and better image quality of 3D FIESTA sequence is used for evaluating bowel inflammation in CD; however, we found 2D SSFSE_DLwith significantly higher SNR and CNR of ileum and terminal ileum than 3D FIESTA and, of course, conventional 2D SSFSE. 2D SSFSE_DL shortened scan time and also offered better image quality than 3D FIESTA in assessment of bowel inflammation in CD. The SSFSE sequence alone has been considered sufficient in lesion detection[2]; SSFSE with DLR has great potential in elevation of detection rate without extra imaging time.

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Yaxin Niu¹, Xiaoyan Lei¹, Li Zhang¹, Min Tang¹, and Kai Ai^2
1Shaanxi Provincial People's Hospital, XI'AN, China, ²Philips Healthcare, XI'AN, China

Keywords: Cancer, Diffusion/other diffusion imaging techniques

We aimed to explore the diagnostic value of amide proton transfer-weighted (APTw) imaging combined with diffusion-weighted imaging (DWI) in differentiating rectal cancer from non-rectal cancer. The result showed that, compared with APTw or DWI (AUC=0.846 and 0.854, respectively), the highest diagnostic efficacy (AUC=0.967) was acquired using APTw combined with apparent diffusion coefficient (ADC) values.

Xiaoling Gong¹, Yu Shen², Xiaoxiao Zhang³, Zhigang Wu³, Ziqiang Wang², and Bing Wu^4
1Department of Radiology, West China Hospital, Sichuan University, Cheng du, China, ²Colorectal Cancer Center，Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China, ³Philips Healthcare, China, Beijing, China, ⁴Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

Keywords: Cancer, Microstructure, rectal cancer

The effectiveness of neoadjuvant Chemotherapy (NACT) is most commonly assessed by the change in tumor size based on conventional rectal cancer imaging. However, morphologic changes often occur later during treatment. Time-Dependent Diffusion MRI (TD MRI) is a novel MRI tool for depicting cellular microstructures. This study aimed to investigate the feasibility of Time-Dependent Diffusion MRI–based microstructural mapping for noninvasively characterizing cellular properties of LARC during NACT.

WEN JUN HU¹, Anliang Chen¹, and AIlian Liu^1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China

Keywords: Digestive, Cancer

Tumor deposits (TDs) in rectal cancer have been shown to be an important marker of poor prognosis. Although very similar to lymph node metastasis (LNMs), TDs have unique features in terms of biology and outcome, suggesting that distinguishing between these two entities may be of great importance. Results of this study indicate iodine-based material-decomposition (MD) images and DCE-MRI can effectively differentiate TDs and LNMs in rectal cancer, and iodine-based MD images showed better diagnostic efficiency.

Weicui Chen¹, Guoqing Liu¹, Jialiang Chen¹, Qiurong Wei¹, Yongsong Ye¹, Xiaohua Du¹, Jiepin Feng¹, Zhaoxian Yan¹, Kan Deng², and Xian Liu^1
1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, ²Philips Healthcare, Guangzhou, China

Keywords: Digestive, Cancer, Rectal neoplasms

This study evaluate amide proton transfer-weighted (APTw) derived whole-tumour histogram analysis parameters in predicting pathological extramural venous invasion (pEMVI) positive status of rectal adenocarcinoma (RA). The method is to calculate APTw histogram parameters between the pEMVI-negative and positive groups, assess the independent risk factors and diagnosis performance. Our results demonstrated that RA with pEMVI-positive status is associated with higher APTw-SI. The best prediction for EMVI involvement was obtained with a combined model of histopathological factors and APTw histogram parameters. Therefore, the APTw histogram analysis may represent a valuable non-invasive tool in predicting pEMVI positive status of RA. 

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Anliang Chen¹, Deshuo Dong¹, Changjun Ma¹, Ailian Liu¹, and Qingwei Song^1
1radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

Keywords: Digestive, Pelvis

Mutant P53 promotes tumor cell proliferation, invasion, and resistance to chemotherapy. The purpose of this study was to evaluate the value of combination of DKI and IVIM for prediction of P53 expression status in rectal cancer. The results indicate that the combination of MK and D* improved the diagnostic efficiency than single parameters. DKI and IVIM imaging allows non-invasive visualization and quantification of tissue composition for prediction of P53 status in rectal cancer.

Haodong Jia^1
1Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China

Keywords: Pelvis, fMRI

This is an abstract by Haodong Jia.

 

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Anliang Chen¹, Deshuo Dong¹, Changjun Ma¹, Ailian Liu¹, and Qingwei Song^1
1radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

Keywords: Cancer, Cancer

Mutant P53 promotes tumor cell proliferation, invasion, and resistance to chemotherapy. The purpose of this study was to evaluate the value of Diffusion Kurtosis Imaging (DKI) for prediction of P53 expression status in rectal cancer. The results indicate that positive P53 status group had significantly lower MD and higher MK values than negative P53 status group. DKI reflect a non-Gaussian phenomenon of water molecules within biologic tissues for prediction of P53 expression status in rectal cancer.

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Anliang Chen¹, Deshuo Dong¹, Changjun Ma¹, Ailian Liu¹, and Qingwei Song^1
1radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

Keywords: Cancer, Digestive

The Ki-67 expression has been verified as a prognostic indicator in colorectal cancer, correlating with biological behavior of tumor and response to the chemotherapy. The purpose of this study was to evaluate the value of intravoxel incoherent motion (IVIM) imaging for prediction of Ki-67 expression status in rectal cancer. The results indicate that high Ki-67 status group had significantly lower ADC and D values than low Ki-67 status group. IVIM imaging allows non-invasive visualization and quantification of tissue composition for prediction of Ki-67 expression status in rectal cancer.