View Presentation Video

Ruoxun Zi¹, Bili Wang¹, Jerzy Walczyk¹, Ryan Brown¹, Catherine Petchprapa¹, James Fishbaugh², Guido Gerig², Kai Tobias Block¹, and Riccardo Lattanzi^1
1The Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Computer Science and Engineering, New York University Tandon School of Engineerin, Brooklyn, NY, United States

Keywords: Joints, MSK, Wrist

Dynamic MRI can be useful for evaluation of wrist instability. However, most available real-time MRI methods are either limited due to their 2D nature or provide only low temporal resolution and insufficient image quality. Here, we propose a novel approach for volumetric dynamic wrist examination by assembling 2D real-time data into 3D snapshots using MRI-visible markers. The method has been demonstrated for ulnar-radial deviation using a flexible wrist coil and 3D-printed support platform for guiding motion. Future work will use a high-resolution static MRI as morphological prior to segment bones on the dynamic volumes and allow for quantitative kinematic assessment.

View Presentation Video

Min Chen^1,2, Chuanli Cheng¹, Chao Zou¹, and Guanxun Cheng^2
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Radiology Department, Peking University Shenzhen Hospital, Shenzhen, China

Keywords: Joints, Quantitative Imaging, axial spondyloarthritis; bone marrow; fatty acids

Changes of bone marrow fatty acids (FAs) composition have been detected in several inflammatory and metabolic diseases by MRI. However, the alteration of sacroiliac FAs composition in axial spondyloarthritis (axSpA) remains unknown. We observed changes of bone marrow FAs composition of the sacroiliac joint in patients with axSpA compared to controls using chemical shift-encoded MRI (CSE-MRI). The changes differed between areas with fat metaplasia and areas without fat metaplasia in axSpA. Our results indicated bone marrow FAs including saturated FA, mono-unsaturated FA and poly-unsaturated FA may play different roles in the pathogenesis of axSpA.

View Presentation Video

Maria Holodov¹, Irit Markus², Chen Solomon¹, Shimon Shahar³, Tamar Blumenfeld-Katzir¹, Yftach Gepner², and Noam Ben-Eliezer^1,4,5
1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, ²Department of Epidemiology and Preventive Medicine, School of Public Health and Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel, ³Center of AI and Data Science (TAD), Tel Aviv University, Tel Aviv, Israel, ⁴Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ⁵Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States

Keywords: Muscle, Skeletal

Post-exercise recovery rate is vital for planning training protocols, maintaining high-level performance, and preventing injuries. Notwithstanding the advancement of noninvasive imaging, there is still a lack in efficient tools for monitoring muscle state and post-exercise due to the relatively small changes in the muscles’ microarchitecture, and the high variability in recovery rate between and within participants. Here we utilized the echo-modulation-curve (EMC) algorithm, a highly accurate and precise tool for mapping T₂ relaxation times, to track muscle damage and recovery following exercise. Results show that this approach provides new insights into the microstructural processes that occur following exercise.

View Presentation Video

Sara E Sacher¹, Elexis Padgett¹, John P Neri¹, Timothy Wright¹, Thomas W Bauer¹, Michael Parides¹, Douglas Padgett¹, Hollis G Potter¹, and Matthew F Koff^1
1Hospital for Special Surgery, New York, NY, United States

Keywords: MSK, MSK, Total hip arthroplasty

Micromotion at interfaces in modular total hip arthroplasties (THAs) induces corrosion and generation of adverse local tissue reactions (ALTRs), potentially leading to premature failure. The flexural rigidities (FR) of THA femoral stem trunnions retrieved from revision surgery were correlated with MRI metrics and histopathological outcomes. Increased FR was associated with osteolysis and a reduced synovial response, while a lower FR was associated with granulomas, different synovitis types, and tissue necrosis. These results indicate that MRI can serve as a useful biomarker of the local tissue response around THA.    

Miyuki Takasu¹, Yasutaka Baba², Konagi Takeda¹, Saki Kawai¹, Hiroaki Sakane¹, Nobuko Tanitame¹, Akihisa Tamura¹, Makoto Iida¹, and Kazuo Awai^3
1Diagnostic Radiology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan, ²Diagnostic Radiology, International Medical Center, Saitama Medical University, Hidaka, Japan, ³Hiroshima University Hospital, Hiroshima, Japan

Keywords: Bone, Machine Learning/Artificial Intelligence

We examined the use of a vision transformer (ViT)-based deep learning model for the task of differentiation between aplastic anemia and myelodysplastic syndrome using lumbar T1-weighted images. Three sagittal images per patient were obtained and made square using zero-padding and were resized (224 × 224). The overall accuracy and area under the curve of the pre-trained ViT model were higher than those of ViT without pre-training, ResNet-110, and BinaryNet at the optimum hyperparameters. We utilized Grad-CAM images to highlight the information that is important for decision-making. ViT combined with Grad-CAM successfully recognized variability in the  distribution of bone marrow components.

View Presentation Video

Rianne A van der Heijden¹, Timothy M Schmidt², Scott B Reeder^1,3,4,5,6, and Ali Pirasteh^1,3
1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Emergency Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Keywords: Skeletal, PET/MR, Multiple Myeloma

In this study we evaluated the diagnostic performance of whole-body T2-weighted imaging with uniform 2-point Dixon fat-suppression for the detection of multiple myeloma. Furthermore, we evaluated the added sensitivity, change in disease stage, and change in treatment plan with the sequential addition of DWI and FDG PET. T2-Dixon demonstrated higher sensitivity than both DWI and PET. Adding DWI did not change stage or treatment plan. However, the addition of PET did change the treatment plan in one patient with extra-osseous disease. Whole-body PET-MRI with T2-Dixon is a promising and efficient tool for assessment of multiple myeloma.

View Presentation Video

Lauriane Jugé^1,2, Angela Liao^1,2, Jade Yeung¹, Fiona Knapman^1,2, Christopher Bull^1,2, Peter Burke^1,3, Elizabeth Brown^1,4, Simon Gandevia^1,2, Danny Eckert^1,5, Jane Butler^1,2, and Lynne Bilston^1,2
1Neuroscience Research Australia, Sydney, Australia, ²University of New South Wales, Sydney, Australia, ³Macquarie Medical School, Macquarie University, Sydney, Australia, ⁴Prince of Wales Hospital, Sydney, Australia, ⁵Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia

Keywords: Muscle, Muscle, electromyography, sleep, tagged MRI

As measured by tagged MRI, inspiratory tongue dilatory movement might be useful to shed new light on mechanisms controlling upper airway dilation in obstructive sleep apnoea (OSA). Nine healthy controls and 37 untreated OSA patients underwent an upper airway MRI scan and tongue intramuscular electromyography (EMG) assessment. Results identified two opposing relationships between inspiratory tongue movement and phasic EMG with variable impacts on upper airway function for controls and OSA patients. These results suggest that there are complex, and unexpected, relationships between neural drive and anterior tongue movement that suggest upper airway function cannot be predicted from EMG alone.  

View Presentation Video

Wanxuan Fang¹, Yijun Mao², Yujie An¹, Hiroyuki Sugimori², Shinji Kiuch³, and Tamotsu Kamishima^2
1Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan, ²Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, ³AIC Yaesu Clinic, Tokyo, Japan

Keywords: Rheumatoid Arthritis, DSC & DCE Perfusion

Volumetry of enhancing pannus can be used as a marker for disease activity in synovial proliferative disorders such as RA. Enhancing pannus quantified by manual outlining as well as semiquantitative visual assessment of synovitis is too time-consuming to be justified in busy clinical practice. Our study showed great potential for automated quantitative segmentation and quantification of enhancing pannus, which would allow for accurate estimation of disease aggressiveness and thus prompt early therapeutic intervention for patients and assessment of treatment efficacy without increasing the burden on physicians.

View Presentation Video

Kavitha Manickam¹, Muhan Shao², Dawei Gui¹, Chitresh Bhushan², and Dattesh D Shanbhag^3
1GE HealthCare, Waukesha, WI, United States, ²GE Global Research, Niskayuna, NY, United States, ³GE Healthcare, Bangalore, India

Keywords: MSK, Machine Learning/Artificial Intelligence, Automatic prescription, coil sensitivity map

Large-FOV, low-resolution 3D surface coil sensitivities maps are acquired as part of pre-scan which is typically used to calibrate the hardware of MRI system. In this abstract, we propose to use the coil sensitivity maps to automatically find the region of interest of spine anatomy. This information can be used to position the scout images accurately and automatically and thereby reduce any repeat of the scout scans and increase throughput. Our proposal does not need any additional scan and utilizes the existing information available in the MRI scanner. 

View Presentation Video

Keywords: Osteoarthritis, MSK

Early hip osteoarthritis is clinically hypothesized to include alterations in joint motion and bone remodeling. This study investigated the relationships between lower-limb joint kinetics and bone remodeling, measured via positron emission tomography. Our results suggest that greater hip flexion and internal rotation loading and more uniform knee abduction loading are associated with bone remodeling and may serve as early biomechanical biomarkers for hip OA. 

View Presentation Video

Anna M Horner¹, Felix M Gonzalez², Courtney N Gleason¹, Amanda Blackmon^3,4, Emma Faulkner^3,5, and David A Reiter^1
1Emory University School of Medicine, Atlanta, GA, United States, ²Radiology, AdventHealth, Orlando, FL, United States, ³Atlanta Dance Medicine, Atlanta, GA, United States, ⁴Physical Therapy, Mercer University, College of Health Professions, Macon, GA, United States, ⁵Dance, Emory University, Atlanta, GA, United States

Keywords: Tendon/Ligament, Low-Field MRI, UTE MRI, SWE, ballet dancers

Multi-echo ultrashort echo time (UTE) MRI provides quantitative structural information on both tendon matrix constituents and water distribution, which influence the mechanical function of tendons. UTE images of professional ballet dancers' Achilles tendons (AT) were combined with Shear Wave Elastography (SWE) Ultrasound (US) measurements of their AT to provide insight on the structure-function. The signal fraction corresponding to the off-resonance relaxation tendon components were found to positively correlate with the long-axis SWE velocity in this dancer cohort.

Kai Ye¹, Huishu Yuan¹, Weifang Zhang², Xianchang Zhang³, and Lihua Zhang^1
1Department of Radiology, Peking University Third Hospital, Beijing, China, ²Peking University Third Hospital, Beijing, China, ³MR Collaboration, Siemens Healthineers Ltd, Beijing, China

Keywords: Bone, Diffusion/other diffusion imaging techniques, Multiple Myeloma

This study investigated the performance of whole-body diffusion-weighted imaging (WBDWI), non-diffusion MRI, and 18F-FDG PET-CT in detecting spinal lesions in patients with an initial diagnosis of multiple myeloma (MM). The results showed that WBDWI discovered more lesions compared with both non-diffusion MRI and 18F-PET-CT. And the detection of spinal lesions in WBDWI was not significantly decreased even with the decreased degree of marrow infiltration in patients with MM. This suggests that WBDWI should be the preferentially recommended examination for patients with an initial diagnosis of MM.

View Presentation Video

Keywords: Bone, Diffusion/other diffusion imaging techniques, intravoxel incoherent motion, diffusion-weighted imaging, iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ), multiple myeloma, treatment response

This study explored the feasibility of IVIM DWI and IDEAL-IQ parameters in evaluating the treatment response of patients with multiple myeloma (MM) who received systemic treatment within 6 months. The results showed that within 6 months after treatment, the changes of D and f values of IVIM DWI in deep-responders before and after treatment were significantly different from those in non-deep responders.This indicates that the changes of D and f values of IVIM DWI may be helpful to evaluate the short-term (within 6 months) therapeutic response of myeloma, while the evaluation of IDEAL-IQ on short-term therapeutic response needs further study.

View Presentation Video

Kihwan Kim¹, Yuran Zhu¹, Raodatullah Abodunrin¹, Sonia Kumar ¹, Jessica Meng¹, Luchen Yu¹, Allison McKenzie ¹, and Xin Yu^1,2
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

Keywords: Muscle, Diabetes

In this study, metabolic responses to 10-week treadmill exercise on obese Zucker rats were examined using ³¹P magnetic resonance spectroscopy. Exercise resulted in improvement in glucose tolerance and aerobic capacity (VO_2max) while retaining mitochondrial oxidative capacity (MOC) and creatine kinase (CK) activity. Sedentary rats, however, showed poor glucose tolerance and reduced VO_2max, which were also marked by significant changes in their MOC and CK activity. 

View Presentation Video

Chao Han¹, Feifei Zhang¹, Chengbin Tian¹, Wenwen Kang¹, Weimin Yu¹, and Jinxia Guo^2
1General Hospital of Pingmei Shenma Group, Pingdingshan, China, ²GE Healthcare, MR Research, Beijing, China

Keywords: Joints, Joints

This study investigated the feasibility and potential advantages of adaptive imaging receiver (AIR) coil for knee imaging. The results show that the SNR and CNR of air coil images were inferior to that of traditional knee coil, but the visual image qualities were comparable between two coils. The air coil can be feasible for knee imaging, especially for patients with large size and double knee imaging.