ISMRM23 - Clinical Translation of Quantitative MRI in MSK

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Clinical Translation of Quantitative MRI in MSK

Sunrise Course

ORGANIZERS: Margaret Hall-Craggs, Fang Liu

Monday, 05 June 2023

715A/B

07:00 - 08:00

Moderators: Valentina Mazzoli & Mikko Nissi

Skill Level: Intermediate to Advanced

Session Number: S-M-04

CME Credit

Session Number: S-M-04

Overview
This course offers an overview of quantitative MRI in musculoskeletal imaging. The speakers will summarize existing challenges in MSK imaging using qualitative MRI, introduce mostly investigated quantitative MRI techniques in MSK imaging, discuss the strengths and weaknesses of quantitative MRI, and finally introduce the Quantitative Imaging Biomarkers Alliance (QIBA) MSK initiative.

Target Audience
Radiologists, clinicians, technologists, and scientists interested in quantitative MRI applied in MSK imaging

Educational Objectives
As a result of attending this course, participants should be able to:
- Summarize the challenges of qualitative MRI in MSK imaging;
- Summarize the strengths and weaknesses of quantitative MRI in MSK imaging; and
- Explain the QIBA MSK initiative.

07:00		What are the current challenges with qualitative musculoskeletal magnetic resonance imaging? View Presentation Video Marcelo Zibetti Keywords: Musculoskeletal: Cartilage, Musculoskeletal: Skeletal, Musculoskeletal: Tendons Qualitative MRI is still the predominant MRI approach in musculoskeletal (MSK) applications. It has many advantages. such as excellent soft-tissue contrast, submillimeter resolution, and the ability to be quickly assessed by our visual system. However, qualitative MRI depends on well-trained radiologists, and the reading of MRI can be subjective, and differ from one reader to another due to several factors. In this talk, we will briefly discuss some of the limitations of qualitative MRI in MSK applications, including cartilage, bone, muscles, tendons, and ligaments.
07:20		What Benefits can Quantitative MRI offer to MSK Imaging? View Presentation Video Vladimir Juras Keywords: Musculoskeletal: Cartilage, Musculoskeletal: Joints Quantitative MRI (qMRI) is a rapidly advancing field in musculoskeletal imaging that allows for more accurate and objective assessment of tissue structure and composition. QMRI techniques can provide measurements of parameters such as T1, T2, T1rho and T2* relaxation times, magnetization transfer ratio (MTR), gagCEST, and diffusion properties. These measurements can be used to detect subtle changes in tissue microstructure. QMRI is particularly useful in evaluating degenerative cartilage disease, bone health, and muscle function. The ability to quantify tissue changes over time can also aid in monitoring disease progression and evaluating the effectiveness of treatments.
07:40		Update of RSNA QIBA MSK qMRI efforts Thomas Link Keywords: Musculoskeletal: Knee, Musculoskeletal: Joints, Musculoskeletal: Cartilage The RSNA Quantitative Imaging Biomarker Alliance (QIBA) mechanism serves to establish and standardize imaging biomarkers. To date there is only one musculoskeletal QIBA committee that works on standardizing the application of T1ρ and T2 imaging as biomarkers for the quantification of cartilage composition. The committee has established claims for these biomarkers and composed a profile which includes requirements and recommendations for MRI acquisition, image analysis, participant handling, image quality assurance, and image interpretation. Currently the QIBA MSK biomarker committee is in the process of testing the profile to document clinical feasibility and assessing performance at different imaging institutions.