ISMRM23 - Non-Standard MR Contrast Mechanisms: From Properties to Function I: Tissue Stiffness: MR Elastography

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Non-Standard MR Contrast Mechanisms: From Properties to Function I: Tissue Stiffness: MR Elastography

Sunrise Course

ORGANIZERS: Karin Shmueli, Cristian Tejos, Richard Thompson, Alex Tze Lun Leong

Monday, 05 June 2023

714A/B

07:00 - 08:00

Moderators: Arvin Arani & Meng Yin

Skill Level: Basic to Intermediate

Session Number: S-M-07

CME Credit

Session Number: S-M-07

Overview
This course with cover the theoretical foundations and applications of imaging modalities that make use of non-standard contrast mechanisms, such as elastography (MRE), magnetic susceptibility (QSM and SWI), electric conductivity (MR EPT), functional susceptibility changes (fQSM), and ultrashort TE (UTE) and zero TE (ZTE) sequences.

Target Audience
This course is designed for scientists and clinicians who are interested in understanding, developing, or applying imaging techniques that make use of non-standard contrast mechanisms, such as elastography (MRE), magnetic susceptibility (QSM), and electric conductivity (MR EPT). The course is also focused on those interested in functional imaging based on changes in susceptibility (fQSM) or those wishing to use ultrashort TE (UTE) and zero TE (ZTE) sequences to scan challenging structures due to their rapid spin-spin relaxation.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the acquisition and processing methods for different MRI approaches with non-traditional contrast mechanisms;
- Discuss the pros and cons of each method; and
- Identify different areas of applications for each method.

07:00		Tissue Stiffness: MR Elastography: Theory View Presentation Video Yuan Feng Keywords: Contrast mechanisms: Elastography This lecture will introduce the fundamentals of tissue stiffness and its measurement using Magnetic Resonance Elastography (MRE). The basics of linear elasticity, such as stress, strain, and shear modulus, will be covered. Wave propagation in materials will be discussed along with the wave equation. Representations of tissue stiffness, i.e., shear stiffness, wave speed, complex modulus, etc., and their physical meanings will also be discussed. Theory and implementations of MRE will be presented. Finally, the inversion algorithms (e.g., direct inversion, local field estimation, finite element method, and machine learning) to estimate tissue stiffness will be discussed.
07:30		Tissue Stiffness: MR Elastography: Case Study/Application View Presentation Video Lauriane Jugé Keywords: Contrast mechanisms: Elastography This talk will present key clinical applications of MR elastography. MR elastography is a useful imaging technique for mapping the mechanical properties of soft tissues in vivo, such as the brain, liver, muscles, or tumours. It is an established diagnostic technique for staging liver fibrosis and has increasing relevance in investigating complex physiological and pathological processes, including neurodegenerative diseases and cancers. Recent advancements in MR elastography, allowing mapping of anisotropic tissue properties and characterisation of nonlinear viscoelastic behaviour under static loading, will also be covered to discuss future applications of MR elastography.