ISMRM23 - Demystifying the fMRI Signal & Its Biophysical Origins IV: Connecting the fMRI Signal to Metabolism

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Demystifying the fMRI Signal & Its Biophysical Origins IV: Connecting the fMRI Signal to Metabolism

Sunrise Course

ORGANIZERS: Natalia Petridou, Rita Schmidt

Thursday, 08 June 2023

716A/B

07:00 - 08:00

Moderators: Richard Edden & Itamar Ronen

Skill Level: Basic to Intermediate

Session Number: S-Th-08

CME Credit

Session Number: S-Th-08

Overview
This is a sunrise educational course on the fMRI signal and its biophysical origins. The course will describe the fMRI biophysical signal origin and modeling, followed by analysis of the systematic and physiological components of the fMRI signal. In addition, the course will connect the fMRI signal to other modalities, including intra-cranial measurements and spectroscopy.

Target Audience
Scientists and clinicians interested in learning/refreshing their knowledge of the biophysical origins of the fMRI signal.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the biophysical origins and biophysical models of the fMRI signal;
- Recognize the systematic and physiological noise contributions to the fMRI signal and review data acquisition methods to characterize the noise;
- Describe how the fMRI signal relates to intra-cranial measurements in animals and electrophysiological measurements in humans; and
- Explain relationships between the fMRI signal and underlying metabolic process, and review combined fMRI and spectroscopy data acquisition approaches.

07:00		Metabolic Underpinnings of the fMRI Signal View Presentation Video Assaf Tal Keywords: Contrast mechanisms: Spectroscopy, Contrast mechanisms: fMRI In this talk I will discuss some of the potential, pitfalls and interpretations of proton functional spectroscopy, or fMRS, for short. I will attempt to provide a broad overview of the field, and, in particular, point out similarities and differences relative to fMRI, and where fMRS might provide added insight to BOLD-fMRI.
07:30		Combined fMRI-MRS Acquisitions View Presentation Video Nathalie Just Keywords: Contrast mechanisms: Spectroscopy, Neuro: Brain function, Contrast mechanisms: fMRI fMRS acquisitions are gradually becoming complementary to fMRI acquisitions providing crucial insights in various functions of the normal and altered human brain. I will summarize the main findings on functional magnetic resonance spectroscopy (fMRS) from its birth until today and demonstrate the power of this technique for investigating the complexities of brain activity showing the importance of the investigations of the neurometabolic properties for a better understanding of the underlying physiological mechanisms through many examples. I will also emphasize the necessity of performing fMRS in rodent models thereby showing the enormous possibilities available from fMRS coupling with optogenetics and chemogenetics.