ISMRM23 - Hyperpolarized MRI & MRS: From Physics to Applications

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

Hyperpolarized MRI & MRS: From Physics to Applications

Weekday Course

ORGANIZERS: Candace Fleischer, Rolf Schulte

Thursday, 08 June 2023

701A

13:45 - 15:45

Moderators: Myriam Chaumeil & Charles Cunningham

Skill Level: Intermediate

Session Number: Th-03

CME Credit

Session Number: Th-03

Overview
In this educational session, the physical basics of hyperpolarization are introduced and its specific requisites in terms of hardware, acquisition, reconstruction, and quantification. The session will conclude with an overview of clinical applications.

Target Audience
Physicists who want to learn how we can boost the signal in MR applications and learn about the fascinating method of hyperpolarization and its applications.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the physics of hyperpolarization, including DNP, SEOP, PHIP;
- Recognize hardware and acquisition challenges;
- Explain specifics to imaging hyperpolarized spins; and
- Outline potential clinical applications.

13:45		Overview of Hyperpolarization View Presentation Video Yuhei Takado Keywords: Contrast mechanisms: Hyperpolarization Hyperpolarization is a powerful technique that enhances NMR signal intensity, and it can be implemented using various methods. This presentation provides an overview of hyperpolarization for medical applications, with a particular focus on dynamic nuclear polarization (DNP), which is now utilized in clinical research. The presentation outlines the fundamentals of hyperpolarization and discusses the necessary components for hyperpolarized magnetic resonance imaging. Additionally, prospects for the field are presented in the hopes of inspiring further research efforts.
14:15		129Xe: Hardware, Acquisition & Reconstruction View Presentation Video Graham Norquay Keywords: Contrast mechanisms: Hyperpolarized MR (Gas), Physics & Engineering: Hardware, Physics & Engineering: Physics This presentation focusses on the optimisation of hardware for polarising ¹²⁹Xe and the methods for acquiring and reconstructing in vivo hyperpolarised ¹²⁹Xe MR data. The technology of ¹²⁹Xe-Rb spin-exchange optical pumping is introduced, followed by a description of the critical steps involved in system characterisation and optimisation. The second part of this talk covers the technical challenges and potential applications of current acquisition and reconstruction methods for in vivo hyperpolarised ¹²⁹Xe MR.
14:45		13C: Hardware, Acquisition & Reconstruction View Presentation Video Irene Marco Rius Keywords: Contrast mechanisms: Hyperpolarization This lecture will give an overview of the workflow of a hyperpolarized 13C-MRSI experiment, with focus on the two main polarization techniques used for biomedical applications of hyperpolarized 13C-labelled nuclei: dissolution Dynamic Nuclear Polarization (dDNP) and Parahydrogen Induced Polarization (PHIP). Concepts related to hardware for hyperpolarization and MRSI signal acquisition, data analysis and validation will be introduced and discussed.
15:15		Clinical applications of Hyperpolarized 13C and 129Xe MRI View Presentation Video Gigin Lin Keywords: Contrast mechanisms: Hyperpolarization, Cross-organ: Cancer, Education Committee: Clinical MRI Hyperpolarized (HP) MRI is an emerging imaging technique to enhance signals of gases (helium-3 or xenon-129) or liquids (carbone-13), to highlight body's internal structures and metabolic processes. Traditional MRI provides detailed images of the anatomy of the body, and HP MRI goes further by providing information about metabolic processes in real-time. Based on its non-invasive and non-irritation nature, HP MRI has gained attentions in wide range of potential clinical applications, including cancer, heart, lung, brain, and metabolic disorders. In this talk we will discuss the clinical potentials of HP MRI through exploring the ongoing research and clinical trials.