ISMRM23 - What Your Neurology Friends Will Soon Be Asking You Re: Imaging of Neuroinflammation

ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

What Your Neurology Friends Will Soon Be Asking You Re: Imaging of Neuroinflammation

Weekday Course

ORGANIZERS: Janine Lupo, Dan Ma, Takeshi Yokoo

Tuesday, 06 June 2023

701A

08:15 - 10:15

Moderators: Se-Hong Oh & Rebecca Samson

Skill Level: Basic to Intermediate

Session Number: Tu-02

CME Credit

Session Number: Tu-02

Overview
This course will cover quantitative multiparametric imaging of neuroinflammation and how to get the most out of your scanner. It will begin with an overview describing how MRI can be used to elucidate the various processes associated with neuroinflammation and what tools are needed in the clinic to image them. Next, we will further dive into individual metrics that can be quantified and how they can be used together and with other modalities such as PET to diagnose neuroinflammation and correlate with outcome measures, including harmonization among multiple sites. Finally, the course will conclude with the clinical impact of including cutting-edge acquisition and analysis technological advances on various neurological diseases that exhibit neuroinflammation.

Target Audience
Clinicians and engineers with an interest in understanding different acquisition and analysis methods for imaging neuroinflammation.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify imaging metrics that correlate with characteristics of neuroinflammation and its downstream effects;
- Describe the benefits of multiparametric and multimodal analysis for a comprehensive evaluation of neuroinflammation; and
- Explain the role of imaging neuroinflammation and potential benefits it has on patient management.

08:15		Imaging Markers of Neuroinflammation View Presentation Video Toshiaki Taoka Keywords: Neuro: Nervous system Neuroinflammation, an immune response in the central nervous system, affects neuronal function. By using neuroimaging techniques such as SPECT, PET, and MRI, markers of neuroinflammation such as microglia activation, blood-brain barrier disruption, and interstitial fluid dynamics can be detected and monitored. These imaging markers are useful in diagnosing and tracking the progression of diseases such as multiple sclerosis, Alzheimer's, and Parkinson's disease.
08:35		Going Multiparametric: Fusing It All Together View Presentation Video Tobias Kober Keywords: Neuro: Brain, Image acquisition: Quantification This talk will try to introduce different perspectives of "fusing" multiparametric data in order to learn more about neuroinflammation. To do so, we will discuss about the concept of qMRI atlases as well as digital twinning illustrated by some real life examples. In the end, a set of hopefully useful ingredients of MRI-based "fusion kitchen" is given.
08:55		Integrating Multiple Modalities View Presentation Video Myriam Chaumeil Keywords: Contrast mechanisms: Hyperpolarization, : Preclinical/Animal, Neuro: Neurodegeneration In this talk, I will discuss how integrating metabolic imaging strategies (e.g hyperpolarized 13C MRI, PET) with MRI and ex vivo analysis can be used to improve our understanding of neuroinflammation, and enable the detection of neuroinflammatory lesions and the monitoring of response to immunomodulatory therapies in Multiple Sclerosis.
09:15		Multisite Harmonization View Presentation Video Kamil Uludag Keywords: Neuro: Neurodegeneration, Neuro: Brain For data collected from multiple sites, the resulting features can be difficult to interpret due to site-specific effects. Nonetheless, for certain studies, such as those requiring a large number of participants, it may be necessary to obtain data from multiple scanners. Thus, harmonization methods have been developed to correct for site effects while still preserving the biological variability in the data. However, several challenges must be carefully considered, including the minimum sample size required and differences in data acquisition procedures. In this presentation, I will discuss these challenges in detail and offer strategies for successful MRI harmonization in multisite studies.
09:35		The Future of MRI for Imaging Neuroinflammation & Its Impact on Patient Care View Presentation Video Mark Lowe Keywords: Neuro: Brain, Neuro: Neurodegeneration, Neuro: Cerebrovascular In this presentation, I will present an overview of potential impact of MRI on the future clinical care of patients with neuroinflammatory diseases.