ISMRM & ISMRT Annual Meeting & Exhibition • 03-08 June 2023 • Toronto, ON, Canada

ISMRM & ISMRT Annual Meeting & Exhibition

Weekend Course

Perfusion & Permeability Throughout the Body

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Perfusion & Permeability Throughout the Body
Weekend Course
ORGANIZERS: Henrik Odéen, Cristian Tejos, Richard Thompson
Saturday, 03 June 2023
714A/B
08:00 -  12:00
Moderators: Hanzhang Lu & Catherine Morgan
Skill Level: Basic to Intermediate
Session Number: WE-05
CME Credit
Session Number: WE-05

Overview
This course introduces the background physics and methods for imaging of perfusion and permeability including dynamic contrast-enhanced (DCE), dynamic-susceptibility contrast (DSC), and non-contrast arterial spin labeling (ASL) methods. Key clinical applications that utilize each method are described.

Target Audience
This course is designed for scientists and clinicians who are interested in imaging perfusion and permeability.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the acquisition and analysis methods for different perfusion imaging approaches;
- Explain the advantages and disadvantages to each perfusion imaging approach; and
- Identify which perfusion imaging approach is best suited for the major distinct clinical applications.
08:00   Perfusion & Permeability: Applications Petra van Houdt

Keywords: Contrast mechanisms: Perfusion, Cross-organ: Cancer

Contrast-based perfusion MRI is used to assess tissue perfusion and permeability. Dynamic susceptibility-contrast (DSC-) MRI is mainly applied in the brain, whereas dynamic contrast-enhanced (DCE-) MRI has applications throughout the body, mostly related to oncology . For example, in cervical cancer it has been shown that DCE-MRI can be used to identify patients with hypoxic tumors, which is related to tumor aggression and resistance toradiation treatment. Clinical adoption of DSC- and DCE-MRI is currently hindered by the lack of reproducibility, non-standardized terminology, and requirements of expert imaging scientists.
08:30 Arterial Spin Labelling (ASL): Methods Laura Parkes

Keywords: Contrast mechanisms: Perfusion, Neuro: Cerebrovascular, Image acquisition: Quantification

I will describe the acquisition and analysis of ASL data in order to produce accurate images of perfusion or blood flow, with a focus on the brain. I will describe recent advances in acquisition to improve SNR and pragmatic approaches to kinetic modelling of the signal for accurate and precise quantification. I will discuss the benefits of multi-time point measurements which allow correction for and estimation of arterial transit time.
09:00   Dynamic Susceptibility Contrast (DSC) Methodology Ona Wu

Keywords: Neuro: Cerebrovascular, Contrast mechanisms: Perfusion, Image acquisition: Image processing

Dynamic susceptibility contrast-weighted MRI (DSC-MRI) is highly sensitive in detecting disturbed hemodynamics. However, many techniques exist for calculating perfusion status, and there are multiple parameters that can be measured. We will discuss technical considerations and potential pitfalls in calculating and interpreting DSC-MRI-derived maps.
09:30   Dynamic Susceptibility Contrast (DSC) Applications Seung Hong Choi

Keywords: Neuro: Brain, Neuro: Cerebrovascular, Contrast mechanisms: Perfusion

Dynamic Susceptibility Contrast (DSC) is a magnetic resonance imaging (MRI) technique that measures changes in magnetic susceptibility caused by the passage of a contrast agent through the cerebral vasculature to assess brain perfusion.   
10:00   Break & Meet the Teachers
 
10:30   Comparison of ASL & DSC Perfusion Greg Zaharchuk
11:00   Quantitative Perfusion Imaging in the Heart: Methods Ganesh Adluru

Keywords: Cardiovascular: Myocardium, Image acquisition: Quantification

Quantitative myocardial perfusion imaging is increasingly being used clinically as a valuable tool for improved detection of perfusion defects arising from coronary artery disease as well as microvascular disease.  A number of frameworks exist for performing quantitative perfusion imaging with combinations of different (i) data acquisition and reconstruction schemes, (ii) post-processing methods and (iii) modeling approaches.  The presentation will give an overview of methods used in each of the three major steps.
11:30   Quantitative Perfusion Imaging in the Heart: Applications Michael Salerno
 

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