ISMRM24 - MRI for Biology-Guided RT: Are We There Yet?

MRI for Biology-Guided RT: Are We There Yet?

Member-Initiated Session

Wednesday, 08 May 2024

Room 325-326

13:30 - 15:30

Moderators: Sirisha Tadimalla & Zhaoyang Fan

Session Number: MIS-02

No CME/CE Credit

OVERVIEW:
This MIS is endorsed by the MR in Radiation Therapy study group.

Biology-guided radiation therapy (RT) is an emerging treatment paradigm where biological imaging informs the planning and delivery of radiation therapy. Several quantitative MRI (qMRI) biomarkers derived from techniques such as diffusion-weighted imaging, dynamic contrast-enhanced MRI, oxygen-enhanced MRI, among others, have shown promise for imaging tissue characteristics such as fibrosis and inflammation, as well as tumour characteristics such as aggressiveness and radio-resistance. The 2022 joint ESTRO-ISMRM symposium brought together experts from RT and MRI to identify challenges for the clinical translation of these biomarkers. Recent literature has shown that advances in this field are rapidly growing, with increasing numbers of qMRI parameters being investigated for their potential use in RT. In this symposium, we will review progress on the adoption of qMRI in clinical RT, including recent and ongoing clinical trials, with a focus on biology-guided RT. We will also review technical challenges related to routine implementation of these methods, providing much food for thought for the MRI community.

The symposium will be organised as a series of talks from speakers with expertise and experience on different qMRI techniques that have been integrated into the RT pipeline for biology-guided RT. These talks will be bookended by an Introduction to the topic and a panel discussion at the close.

TARGET AUDIENCE:
Members of the MR in RT study group and other MRI scientists, physicists, and technologists interested in the application of MRI in radiation therapy.

AS A RESULT OF ATTENDING THIS COURSE, PARTICIPANTS SHOULD BE ABLE TO:
- Know of current research on MRI techniques to quantify tumour or tissue biology;
- Develop expertise on the integration of qMRI in clinical trials; and
- Identify key challenges or barriers for routine implementation of qMRI for biology-guided RT

13:30		Introduction Jie Deng University of Texas Southwestern, Dallas, TX, United States
13:43		Spectroscopic MRI-Guided Radiation Therapy Peter Barker Johns Hopkins University, Baltimore, MD, United States
13:56		Oxygen-Enhanced MRI in Radiation Therapy Stefan Reinsberg University of British Columbia, Vancouver, BC, Canada
14:09		Four-Dimensional Magnetic Resonance Fingerprinting (4DMRF) for Liver Cancer Radiotherapy Jing Cai Hong Kong Polytechnic University, Hong Kong, China
14:22		MRI-Guided Functional Sparing in Liver Radiation Treatment Planning Jonathan Goodwin Calvary Mater Newcastle, Newcastle, Australia
14:35		129Xe Gas Exchange MRI for Functional-Avoidance RT Planning & Early Detection of Radiation-Induced Lung Injury Leith Rankine University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
14:48		Technical Challenges in Integrating MRI Biomarkers for Biology-Guided RT Erin (Yu-Feng) Wang University of Sydney, Camperdown, Australia
15:01		Towards Implementation of BIGART in Clinical Practice Petra van Houdt The Netherlands Cancer Institute, Amsterdam, Netherlands
15:14		Panel Discussion

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