ISMRM & ISMRT Annual Meeting & Exhibition • 04-09 May 2024 • Singapore

ISMRM & ISMRT 2024 Annual Meeting & Exhibition

Plenary Session

Thursday Plenary

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Thursday Plenary
Plenary Session
ORGANIZERS: Emmanuel Barbier, Candace Fleischer, Shaihan Malik, Andrew Scott, Dan Wu
Thursday, 09 May 2024
Plenary Hall (Hall 603-604)
10:30 -  12:00
Moderators: Candace Fleischer & Andrew Scott
Session Number: P-04
CME Credit
Session Number: P-04

Overview
As MR scientists, we frequently measure parameters that we attribute to a straightforward physical or physiological property or process. However, biological tissue is highly heterogeneous on multiple-length scales and this heterogeneity inevitably leads to exchange between the different compartments or pools. The exchange may be of energy or water molecules themselves, but it is frequently this exchange that underpins the additional complexity hidden within our “simple” quantitative MR measures. In this plenary session, we will explore three aspects of exchange in MR that are frequently neglected and/or result in systematic biases and/or present opportunities for novel biomarkers of physiological processes.

Target Audience
Scientists, engineers, researchers, clinicians, technologists, and trainees at any career stage interested in or utilizing MRI.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify sources of molecular and energy exchange in biological tissues
- Differentiate between exchange mechanisms across multiple time scales
- Recognise the effects of exchange in routine and research MR applications
- Interpret the results of exchange sensitive MR experiments
 
10:30   The Basics: Dynamics of Water & Other Molecules in Biological Tissue
Olivier Girard

Keywords: Contrast mechanisms: CEST & MT, Contrast mechanisms: Relaxometry, Contrast mechanisms: Microstructure

Biological tissues are dynamically heterogeneous spin systems containing a large variety of proton-carrying molecules, evolving in different magnetic environments, and exchanging magnetization over the time course of an MRI experiment. The MRI signal is typically measured from free water, but it carries the signature of the interactions the water protons have evolved through. Hence “free water” relaxation globally reflects on multiple contributions of different types of protons, including water protons in different magnetic environments and other exchanging non water protons. This lecture aims at building intuition on the basic principles of relaxation and magnetization transfer effects occurring in biological tissues.
11:00   Why Does Exchange Matter in MR?
Penny Gowland
11:30   Water Exchange Across Biological Barriers as a Biomarker
Ruiliang Bai

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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.