ISMRM24 - Imaging of the Marrow

Imaging of the Marrow

Weekday Course

ORGANIZERS: Margaret Hall-Craggs, Jamie MacKay

Wednesday, 08 May 2024

Summit 1

15:45 - 17:45

Moderators: Rajpaul Attariwala & Xiufeng Li

Skill Level: Intermediate to Advanced

Session Number: W-03

CME Credit

Session Number: W-03

Overview
The session will start with an overview of bone marrow anatomy, physiology and pathology, given by experts in these respective fields. We then consider which MR (and other) imaging methods are available to assess bone marrow pathology with a particular focus on the use of whole body MRI in oncologic and non-oncologic marrow disease.

Target Audience
Clinicians and scientists interested in understanding bone marrow physiology and pathology.

Educational Objectives
As a result of attending this course, participants should be able to:
- Define the structure, function, physiology and endocrine influence of the bone marrow;
- Describe how disease can disrupt the structure and function of bone marrow; and
- Identify the best MRI tools and methodologies for interrogating bone marrow in health and disease.

15:45		What’s in the Marrow? View Presentation Video Jabed Iqbal
16:15		What’s Wrong with the Marrow? View Presentation Video Lianne Lee
16:45		Interrogating Bone Marrow View Presentation Video Timothy Bray Keywords: Musculoskeletal: Skeletal This talk will discuss MRI methods for interrogating the bone marrow, building on the previous lectures that introduced the physiology and pathophysiology of the marrow. The discussion will focus on how MRI can be used to measure the size and properties of the key marrow compartments: the cellular and extracellular compartments, the fat compartment, the vascular compartment and trabecular compartment. Particular emphasis will be given to how MRI can be used to disentangle different marrow processes, thus enabling ‘confounder-corrected’ assessments of pathophysiology.
17:15		Whole-Body MRI in Marrow Evaluation View Presentation Video Rianne van der Heijden Keywords: Musculoskeletal: Skeletal, Image acquisition: Whole body Whole body MRI has shown promise in bone marrow evaluation, for instance in diagnosing and staging of oncologic, inflammatory and metabolic diseases. In many cases, whole body multi-parametric MRI surpasses other modalities and thus is increasingly implemented in international clinical guidelines. However, whole body MRI faces several practical and technical challenges, such as long scan duration and B0 inhomogeneity. We will review the opportunities and challenges of often used imaging like fat-water separation, diffusion and perfusion. In addition, potential future solutions will be discussed and some practical insights will be shared.