ISMRM24 - Imaging of Fibrosis Across the Body

Imaging of Fibrosis Across the Body

Weekend Course

ORGANIZERS: Jonathan Dillman, Dan Wu

Saturday, 04 May 2024

Nicoll 2

08:00 - 11:30

Moderators: Richard Ehman & Rianne van der Heijden

Skill Level: Basic to Advanced

Session Number: WE-06

CME Credit

Session Number: WE-06

Overview
In this session, we will review the pathogenesis of tissue/organ fibrosis, an aberrant reparative process that occurs in nearly all tissues and organs as the result of chronic and/or repetitive injury. The imaging of fibrosis across a variety of tissues/organs will be discussed. Speakes will present how we have we imaged fibrosis in the past using MRI, how we currently image fibrosis, and emerging techniques for fibrosis assessment.

Target Audience
The intended target audience includes trainees, physicians who perform fibrosis evaluation in the clinic, and scientists/PhDs with an interests in the MRI assessment of fibrosis and tissue characterization.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe why and how fibrosis occurs in human tissues/organs;
- Explain current imaging MRI methods for detecting and measuring fibrosis in a variety of tissues/organs; and
- Recognize emerging methods for detecting and measuring fibrosis across the body.

08:00		Introduction Richard Ehman¹, Rianne van der Heijden² ¹, ²
08:10		MRI of Cardiac Fibrosis View Presentation Video Lorna Browne
08:40		MRI of Hepatic Fibrosis View Presentation Video Kartik Jhaveri
09:10		MRI of Renal Fibrosis View Presentation Video Lilach Lerman Keywords: Body: Kidney Motivation: Early identification of tissue fibrosis may be useful for the management of patients with renal disease but is difficult to achieve in vivo non-invasively. Goal(s): We evaluated the ability of Magnetic resonance imaging (MRI) techniques to quantify renal fibrosis. Results: MRI can assess renal fibrosis using through its impact on renal functional, structural, mechanical, and molecular attributes. Some available tools may not be specific to fibrosis alone and could be used in tandem with other indices of kidney damage and dysfunction. Impact: Modulation of renal microstructure induced by renal fibrosis is detectable by MRI and could be clinically useful.
09:40		Break & Meet the Teachers
10:10		MRI of Intestinal Fibrosis View Presentation Video Kim Beek
10:40		MRI of Pulmonary Fibrosis View Presentation Video Gael Dournes Keywords: Body: Lung, Image acquisition: Multiparametric, Contrast mechanisms: Non-Proton To assess interstitial lung disease (ILD), chest MRI has been historically out of the scope of clinical imaging because of technical difficulties such as low proton density and respiratory and cardiac motion. However, technological breakthroughs have emerged that dramatically improve lung MRI quality. At the same time, novel treatment approaches are changing the landscape of clinical care. Also, MRI may offer the ability to differentiate active inflammation vs scarring tissue. This presentation aims to review the most recent developments of lung MRI in ILD, and the perspectives on how these modern techniques may converge and could impact patient care soon.
11:10		Q & A