Oliver Gurney-Champion

Keywords: Contrast mechanisms: Diffusion, Contrast mechanisms: Perfusion, Cross-organ: Tissue characterisation

Intravoxel Incoherent Motion (IVIM) presents a compelling approach to studying tissue (micro)circulation and perfusion. In this talk, we explore why IVIM is a valuable tool in medical imaging and how it differs from other perfusion measures. By dissecting the principles behind IVIM, we uncover its ability to differentiate between diffusion and (microvascular) perfusion in tissue, offering insights into various pathologies. Moreover, we will touch upon the different mechanisms and assumptions behind the IVIM signal model and discuss when they hold and when not.

Oscar Jalnefjord

Keywords: Contrast mechanisms: Perfusion, Image acquisition: Quantification, Contrast mechanisms: Diffusion

This lecture provides an overview of methodological aspects of the process to generate intravoxel incoherent motion (IVIM) parameter maps. We will cover both image acquisition, (diffusion encoding, readout methods, other preparation modules) and image processing (preprocessing, choice of model, methods for parameter estimation), all with an emphasis on the perfusion-related IVIM parameters.

Eric Sigmund

Keywords: Image acquisition: Quantification, Contrast mechanisms: Diffusion, Cross-organ: Tissue characterisation

Intravoxel incoherent motion (IVIM) is a quantitative imaging technique that has matured to the point of significant evidence generation in single site studies, but opportunities and challenges still remain to promote it to the next level of broad clinical impact.  In this presentation, I will review the motivation, processes, and initial recommendations generated from recent consensus efforts in the field of intravoxel incoherent motion (IVIM).  These aspects include reviews of recent literature as well as activities held at a recent workshop dedicated to this subject.

Jacobus Jansen

Penny Gowland

Shintaro Ichikawa

Keywords: Body: Liver, Body: Kidney, Contrast mechanisms: Diffusion

The liver is a highly vascularized organ; therefore, perfusion-related effects are not negligible for diffusivity assessment using DWI. IVIM is an imaging technique used to simultaneously estimate perfusion-related and pure molecular diffusivities through analysis of the signal decay of multi-b-value diffusion-weighted images. Fibrosis and cirrhosis can result in significant changes in the histopathological structure of the liver, which consequently leads to pronounced alterations in the ADC and IVIM parameters. Compared with conventional or morphological imaging, IVIM provides additional information that can aid in screening and diagnosis for the liver, kidneys, pancreas, and bowel.