Last updated Tuesday, 31 March 2009

PROGRAM
Educational Objectives:
Upon completion of this workshop, participants should be able to:
   Explain the use of in vivo MR methods to characterize white matter changes in the brain;
  Describe the main histological and MRI findings in normal and disease states of the aging brain;
  Design in vivo human experiments using advanced quantitative MR methods;
  Evaluate the potential role of advanced MR-based measurements as surrogate markers of disease in clinical treatment trials of age-related diseases.
Wednesday, 20 October
18:00 - 20:00 Registration and Poster Set-up

Thursday, 21 October
08:30 Welcome
I. Definitions of Normal Cerebral Aging
08:45

 		 Neurobiological and Neuropsychological Manifestations of Brain Aging
Marilyn Albert, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
 
09:10

 		 Common Anatomic and Histologic Findings in Normal Aging
Douglas L. Rosene, Ph.D., Boston University School of Medicine, Boston, Massachusetts, USA
 
09:35

 		 Cortical and Subcortical Changes in Normal Aging
Ron Killiany, Ph.D., Boston University, Boston, Massachusetts, USA
 
10:00


 		 Proffered Paper:
Global and Regional Brain Volume and Cognitive Aging Over the Lifespan
Roger T. Staff, University of Aberdeen, Aberdeen, Grampian, England, UK
 
10:10
 		 Break
 
10:40

 		 White Matter T2 Relaxation Changes in Normal Aging
George Bartzokis, M.D., University of California, Los Angeles, California, USA
 
11:05

 		 MRI Estimates of Volumetric Changes in White Matter and Gray Matter
Charles Guttmann, M.D., Harvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts, USA
 
11:30
 		 MR Spectroscopy Findings in the Aging Brain
Michael W. Weiner, M.D., University of California at San Francisco, San Francisco, California, USA
11:55 Poster Session
II. Histopathology and MRI of Age-Related Disease States
13:30

 		 Neuropathology of the Cerebral White Matter in Aging and Alzheimer's Disease
Ron Killiany, Ph.D., Boston University, Boston, Massachusetts, USA
 
13:55

 		 Risk Factors for Development of Cerebrovascular Disease and (Silent) MRI Findings in Normal Aging and Age-Related Disease
Monique Breteler, Ph.D., Erasmus Medical Center, Rotterdam, Netherlands
 
14:20

 		 CADASIL
Marc A. Van Buchem, M.D., Ph.D., Leiden University Medical Center, Leiden, Netherlands
 
14:45

 		 The Role of Growth and Repair Processes in Aging
Gwendolyn Kartje, M.D., Ph.D., Loyola University, Mayfield, Illinois, USA
 
15:10
 		 Break
 
15:40

 		 How Do MRI Measurements Reflect WM Changes?
Greg J. Stanisz, Ph.D., University of Toronto, Toronto, Ontario, Canada
 
16:05


 		 Proffered Paper:
Pronounced Iron-Dependent T2 Reduction in Both White and Gray Matter in Aceruloplasminemia
John F. Schenck, M.D., Ph.D., GE Corporate R & D Center, Schenectady, New York, USA
 
16:15
 		 Alzheimer's Disease Neuroimaging Initiative
Michael W. Weiner, M.D., University of California at San Francisco, San Francisco, California, USA
17:00 Adjournment

Friday, 22 October
III. Clinical Expression and MRI Correlates of Age-Related Cerebral Disease
08:00

 		 Neuropsychological Manifestations of Aging: Where Does Normal Aging End (and Alzheimer's Start)?
Yaakov Stern, Ph.D., Columbia University, New York, New York, USA
 
08:30

 		 Role of White Matter in Cognitive Decline and Alzheimer's Disease
Frederik Barkhof, M.D., Ph.D., VU Medical Centre, Amsterdam, Netherlands
 
09:00

 		 White Matter Disease and Gait Impairment
Leslie Wolfson, M.D., University of Connecticut, Farmington, Connecticut, USA
 
09:30


 		 Proffered Paper:
Cerebral Vascular and CSF Flow Dynamics and Age-Related White Matter Changes in "Mild Cognitive Impairment": A MR Study
M.C.H. Feugeas, M.D., Ph.D., Hopital Bichat Claude Bernard, Paris, France
 
09:40

 		 T2-Shortening and Age-Related Dysfunction: A Role for Iron?
Rohit Bakshi, M.D., Brigham and Women's Hospital, Boston, Massachusetts, USA
 
10:10
 		 Break
 
10:40

 		 Diffusion Tensor Imaging: A New Window on the White Matter Architecture of Cognitive Dysfunction?
A. Gregory Sorensen, M.D., Massachusetts General Hospital, Charlestown, Massachusetts, USA
 
11:10


 		 Proffered Paper:
DTI of Cerebral White Matter: Implications for Age-Related Changes in Visual Attention
David J. Madden, Ph.D., Duke University Medical Center, Durham, North Carolina, USA
 
11:20
 		 Functional MRI Studies of Memory in Aging and Early Alzheimer's Disease: Evidence for Compensatory Activation
Reisa Sperling, M.D., Brigham and Women's Hospital, Boston, Massachusetts, USA
11:50 Technology Workshops - Introduction
  • The Evolution of Quantitative MRI in White Matter Disease of the Brain
    Christos Davatzikos, Ph.D., University of Pennsylvania, Philadelphia, PA, USA
12:20 Poster Session
14:00 Technology Workshops (Session A)
Rm. 214



 		 Brain Morphometry (Segmentation, Registration, Cortical Thickness, Voxel-Based Morphometry)
John P. Mugler III, Ph.D., University of Virginia, Charlotte, Virginia, USA
Simon K. Warfield, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
Jack H. Simon, M.D., Ph.D., University of Colorado, Denver, Colorado, USA
 
Rm. 216


 		 fMRI and Voxel-Based Time-Series Analysis
Dominik S. Meier, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
Lawrence Panych, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
 
Rm. 217


 		 Parametric MRI: T2; T1; MTR
Robert V. Mulkern, Jr., Harvard Medical School, Boston, Massachusetts, USA
Joseph McGowan, Ph.D., United States Naval Academy, Annapolis, Maryland, USA
Franz Fazekas, M.D., University of Graz, Graz, Austria
15:30 Break
16:00 Technology Workshops (Session B)
Rm. 214



 		 Spectroscopy
Douglas L. Arnold, M.D., Montreal Neurological Institute, Montréal, Québec, Canada
Oded Gonen, Ph.D., New York University, New York, New York, USA
Michael W. Weiner, M.D., University of California, San Francisco, California, USA
 
Rm. 216


 		 Perfusion Imaging
David C. Alsop, M.D., Ph.D., Harvard Medical School, Boston, Massachusetts, USA
J. Ross Mitchell, Ph.D., Seaman Family MR Research Center, Calgary, Alberta, Canada
 
Rm. 217


 		 DTI/Fiber Tracking
Peter Van Zijl, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
Carl-Fredrik Westin, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
 
Saturday, 23 October
08:00 Technology Workshops - Introduction
  • How Does the MR Surrogate Marker in the MS Model Apply to AD and Age-Related Diseases
    Massimo Filippi, M.D., Istituto Scientifico Universitario San Raffaele, Milano, Italy
08:30 Technology Workshops (Session C)
Rm. 214



 		 Brain Morphometry (Segmentation, Registration, Cortical Thickness, Voxel-Based Morphometry)
John P. Mugler III, Ph.D., University of Virginia, Charlotte, Virginia, USA
Simon K. Warfield, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
Jack H. Simon, M.D., Ph.D., University of Colorado, Denver, Colorado, USA
 
Rm. 216


 		 Perfusion Imaging
David C. Alsop, M.D., Ph.D., Harvard Medical School, Boston, Massachusetts, USA
J. Ross Mitchell, Ph.D., Seaman Family MR Research Center, Calgary, Alberta, Canada
 
Rm. 217

 		 DTI/Fiber Tracking
Peter Van Zijl, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
Carl-Fredrik Westin, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
10:00 Break
10:30 Technology Workshops (Session D)
Rm. 214



 		 Spectroscopy
Douglas L. Arnold, M.D., Montreal Neurological Institute, Montréal, Québec, Canada
Oded Gonen, Ph.D., New York University, New York, New York, USA
Michael W. Weiner, M.D., University of California, San Francisco, California, USA
 
Rm. 216


 		 fMRI and Voxel-Based Time-Series Analysis
Dominik S. Meier, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
Lawrence Panych, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
 
Rm. 217


 		 Parametric MRI: T2; T1; MTR
Robert V. Mulkern, Jr., Harvard Medical School, Boston, Massachusetts, USA
Joseph McGowan, Ph.D., United States Naval Academy, Annapolis, Maryland, USA
Franz Fazekas, M.D., University of Graz, Graz, Austria
12:00 Poster Awards Lunch
- Including 10 minute lectures by the three winners of the poster competition.
IV. Interventions and Surrogate Markers in Age-Related Cerebral Disease
13:30

 		 Biomarkers and MRI findings in age-related neurodegenerative diseases
Steven M. Greenberg, M.D., Ph.D., Harvard Medical School, Boston, Massachusetts, USA
 
14:00

 		 The Role of White Matter Abnormalities as an Outcome Measure in Intervention Studies
Reinhold Schmidt, M.D., University of Graz, Graz, Austria
 
14:30

 		 fMRI of Healthy Aging, (Early) Dementia and Medication Treatment
Serge A. R. B. Rombouts, VU Medical Centre, Amsterdam, The Netherlands
 
15:00


 		 Proffered Paper:
Lack of Incidental DWI Hypertense Lesions in Healthy Elderly Individuals
Dr. Kristina Szabo, University of Heidelberg, Mannheim, Germany
 
15:10
 		 Break
 
15:40

 		 PWI/DTI in White Matter (Lesions) and Prediction of Future Stroke
Steven Warach, M.D., National Institutes of Health, Bethesda, Maryland, USA
16:10
 		 Immunotherapy of Alzheimer's Disease
Howard L. Weiner, M.D., Harvard Medical School, Boston, Massachusetts, USA
16:40 Adjournment