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Last updated
Tuesday, 31 March 2009 |
PROGRAM |
Educational
Objectives:
Upon completion of this workshop, participants should be able to:
Explain the use of in vivo MR methods to characterize white
matter changes in the brain;
Describe
the main histological and MRI findings in normal and disease states of the aging brain;
Design in
vivo human experiments using advanced quantitative MR methods;
Evaluate
the potential role of advanced MR-based measurements as surrogate markers of disease in
clinical treatment trials of age-related diseases. |
Wednesday, 20 October |
18:00 - 20:00 |
Registration and Poster Set-up |
Thursday, 21 October |
08:30 |
Welcome |
I. Definitions of Normal Cerebral Aging |
|
08:45
|
Neurobiological and Neuropsychological Manifestations of Brain Aging
Marilyn Albert, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
|
09:10
|
Common Anatomic and Histologic Findings in Normal Aging
Douglas L. Rosene, Ph.D., Boston
University School of Medicine, Boston, Massachusetts, USA
|
09:35
|
Cortical and Subcortical Changes in Normal Aging
Ron Killiany, Ph.D., Boston University, Boston, Massachusetts, USA
|
10:00
|
Proffered Paper:
Global and Regional Brain Volume and Cognitive Aging Over the
Lifespan
Roger T. Staff, University of Aberdeen, Aberdeen, Grampian,
England, UK
|
10:10
|
Break
|
10:40
|
White Matter T2 Relaxation Changes in Normal Aging
George Bartzokis, M.D., University of California, Los Angeles, California, USA
|
11:05
|
MRI Estimates of Volumetric Changes in White Matter and Gray Matter
Charles Guttmann, M.D., Harvard Medical School, Brigham & Women's Hospital,
Boston, Massachusetts, USA
|
11:30
|
MR Spectroscopy Findings in the Aging Brain
Michael W. Weiner, M.D., University of California at San Francisco, San Francisco,
California, USA |
|
|
11:55 |
Poster
Session |
II. Histopathology
and MRI of Age-Related Disease States |
|
13:30
|
Neuropathology of the Cerebral White
Matter in Aging and Alzheimer's Disease
Ron Killiany, Ph.D., Boston University, Boston, Massachusetts,
USA
|
13:55
|
Risk Factors for Development of Cerebrovascular Disease and (Silent) MRI
Findings in Normal Aging and Age-Related Disease
Monique Breteler, Ph.D., Erasmus Medical Center,
Rotterdam, Netherlands
|
14:20
|
CADASIL
Marc A. Van Buchem, M.D., Ph.D., Leiden University Medical Center, Leiden,
Netherlands
|
14:45
|
The Role of Growth and Repair Processes in Aging
Gwendolyn Kartje, M.D., Ph.D., Loyola University, Mayfield, Illinois, USA
|
15:10
|
Break
|
15:40
|
How Do MRI Measurements Reflect WM Changes?
Greg J. Stanisz, Ph.D., University of Toronto, Toronto, Ontario, Canada
|
16:05
|
Proffered Paper:
Pronounced Iron-Dependent T2 Reduction in Both White and Gray Matter in
Aceruloplasminemia
John F. Schenck, M.D., Ph.D., GE Corporate R & D Center,
Schenectady, New York, USA
|
16:15
|
Alzheimer's Disease Neuroimaging
Initiative
Michael W. Weiner, M.D., University of California at San
Francisco, San Francisco, California, USA |
|
17:00 |
Adjournment |
Friday,
22 October |
III. Clinical
Expression and MRI Correlates of Age-Related Cerebral Disease |
|
08:00
|
Neuropsychological Manifestations of
Aging: Where Does Normal Aging End (and Alzheimer's Start)?
Yaakov Stern, Ph.D., Columbia University, New York, New York,
USA
|
08:30
|
Role of White Matter in Cognitive Decline and Alzheimer's Disease
Frederik Barkhof, M.D., Ph.D., VU Medical Centre, Amsterdam, Netherlands
|
09:00
|
White Matter Disease and Gait Impairment
Leslie Wolfson, M.D., University of Connecticut, Farmington, Connecticut, USA
|
09:30
|
Proffered Paper:
Cerebral Vascular and CSF Flow Dynamics and Age-Related White Matter
Changes in "Mild Cognitive Impairment": A MR Study
M.C.H. Feugeas, M.D., Ph.D., Hopital Bichat Claude Bernard, Paris,
France
|
09:40
|
T2-Shortening and Age-Related Dysfunction: A Role for Iron?
Rohit Bakshi, M.D., Brigham and Women's Hospital, Boston, Massachusetts, USA
|
10:10
|
Break
|
10:40
|
Diffusion Tensor Imaging: A New Window on the White Matter Architecture
of Cognitive Dysfunction?
A. Gregory Sorensen, M.D., Massachusetts General Hospital, Charlestown,
Massachusetts, USA
|
11:10
|
Proffered Paper:
DTI of Cerebral White Matter: Implications for Age-Related Changes in
Visual Attention
David J. Madden, Ph.D., Duke University Medical Center, Durham,
North Carolina, USA
|
11:20
|
Functional MRI Studies of Memory in Aging
and Early Alzheimer's Disease: Evidence for Compensatory Activation
Reisa Sperling, M.D., Brigham and Women's Hospital, Boston,
Massachusetts, USA |
|
11:50 |
Technology
Workshops - Introduction
- The Evolution of Quantitative MRI in White Matter
Disease of the Brain
Christos Davatzikos, Ph.D., University of Pennsylvania,
Philadelphia, PA, USA
|
|
12:20 |
Poster
Session |
14:00 |
Technology
Workshops (Session A)
Rm. 214
|
Brain Morphometry (Segmentation, Registration, Cortical Thickness,
Voxel-Based Morphometry)
John P. Mugler III, Ph.D., University of Virginia, Charlotte, Virginia, USA
Simon K. Warfield, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
Jack H. Simon, M.D., Ph.D., University of Colorado, Denver, Colorado, USA
|
Rm. 216
|
fMRI and Voxel-Based Time-Series Analysis
Dominik S. Meier, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
Lawrence Panych, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
|
Rm. 217
|
Parametric MRI: T2; T1; MTR
Robert V. Mulkern, Jr., Harvard Medical School, Boston, Massachusetts, USA
Joseph McGowan, Ph.D., United States Naval Academy, Annapolis, Maryland, USA
Franz Fazekas, M.D., University of Graz, Graz, Austria |
|
|
15:30 |
Break |
16:00 |
Technology
Workshops (Session B)
Rm. 214
|
Spectroscopy
Douglas L. Arnold, M.D., Montreal Neurological Institute, Montréal, Québec,
Canada
Oded Gonen, Ph.D., New York University, New York, New York, USA
Michael W. Weiner, M.D., University of California, San Francisco, California, USA
|
Rm. 216
|
Perfusion Imaging
David C. Alsop, M.D., Ph.D., Harvard Medical School, Boston, Massachusetts, USA
J. Ross Mitchell, Ph.D., Seaman Family MR Research Center, Calgary, Alberta, Canada
|
Rm. 217
|
DTI/Fiber Tracking
Peter Van Zijl, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
Carl-Fredrik Westin, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
|
|
|
Saturday, 23 October |
08:00 |
Technology
Workshops - Introduction
- How Does the MR Surrogate Marker in the MS Model Apply to AD and
Age-Related Diseases
Massimo Filippi, M.D., Istituto Scientifico Universitario San Raffaele, Milano,
Italy
|
|
08:30 |
Technology
Workshops (Session C)
Rm. 214
|
Brain Morphometry (Segmentation, Registration, Cortical Thickness,
Voxel-Based Morphometry)
John P. Mugler III, Ph.D., University of Virginia, Charlotte, Virginia, USA
Simon K. Warfield, Ph.D., Harvard Medical School, Boston, Massachusetts, USA
Jack H. Simon, M.D., Ph.D., University of Colorado, Denver, Colorado, USA
|
Rm. 216
|
Perfusion Imaging
David C. Alsop, M.D., Ph.D., Harvard Medical School, Boston, Massachusetts, USA
J. Ross Mitchell, Ph.D., Seaman Family MR Research Center, Calgary, Alberta, Canada
|
Rm. 217
|
DTI/Fiber Tracking
Peter Van Zijl, Ph.D., Johns Hopkins University, Baltimore, Maryland, USA
Carl-Fredrik Westin, Ph.D., Harvard Medical School, Boston, Massachusetts, USA |
|
|
10:00 |
Break |
10:30 |
Technology
Workshops (Session D)
Rm. 214
|
Spectroscopy
Douglas L. Arnold, M.D., Montreal Neurological Institute, Montréal, Québec,
Canada
Oded Gonen, Ph.D., New York University, New York, New York, USA
Michael W. Weiner, M.D., University of California, San Francisco, California, USA
|
Rm. 216
|
fMRI and Voxel-Based Time-Series Analysis
Dominik S. Meier, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
Lawrence Panych, Ph.D, Brigham & Women's Hospital, Boston, Massachusetts, USA
|
Rm. 217
|
Parametric MRI: T2; T1; MTR
Robert V. Mulkern, Jr., Harvard Medical School, Boston, Massachusetts, USA
Joseph McGowan, Ph.D., United States Naval Academy, Annapolis, Maryland, USA
Franz Fazekas, M.D., University of Graz, Graz, Austria |
|
|
12:00 |
Poster
Awards Lunch
- Including 10 minute lectures by the three winners of the
poster competition. |
|
IV. Interventions
and Surrogate Markers in Age-Related Cerebral Disease |
|
13:30
|
Biomarkers and MRI findings in age-related neurodegenerative diseases
Steven M. Greenberg, M.D., Ph.D., Harvard Medical School, Boston, Massachusetts, USA
|
14:00
|
The Role of White Matter Abnormalities as an Outcome Measure in
Intervention Studies
Reinhold Schmidt, M.D., University of Graz, Graz, Austria
|
14:30
|
fMRI of Healthy Aging, (Early) Dementia and
Medication Treatment
Serge A. R. B. Rombouts, VU Medical Centre, Amsterdam, The Netherlands
|
15:00
|
Proffered Paper:
Lack of Incidental DWI Hypertense Lesions in Healthy Elderly Individuals
Dr. Kristina Szabo, University of Heidelberg, Mannheim, Germany
|
15:10
|
Break
|
15:40
|
PWI/DTI in White Matter (Lesions) and Prediction of Future Stroke
Steven Warach, M.D., National Institutes of Health, Bethesda, Maryland, USA |
16:10
|
Immunotherapy of Alzheimer's Disease
Howard L. Weiner, M.D., Harvard Medical School, Boston, Massachusetts, USA |
|
16:40 |
Adjournment |
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