ISMRM Workshop on Methods for Quantitative Diffusion MRI of Human Brain

Program with Recorded Presentations

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Saturday, 12 March
17:00-19:00	Dinner, Registration and Poster set-up
Sunday, 13 March
07:30	Breakfast
08:00	Welcome to Alberta **Christian Beaulieu, Ph.D., University of Alberta, Edmonton, Alberta, Canada**
	Opening Address **Carlo Pierpaoli, M.D., Ph.D., National Institutes of Health, Bethesda, Maryland, USA**
08:15	Opening Presentation: Survey and current status of research on biophysical issues in diffusion MRI of brain. Progress since the last workshop in St. Malo. Jeffrey Joseph Neil, MD,PhD, St. Louis Children's Hospital, St. Louis, MO, US
SESSION 1: Clinical Applications of Quantitative Diffusion The aim of this session is to provide clinical "state of the field" talks. Presentations will describe why diffusion MRI is important for the disease state in question and what useful insight it can yield for understanding the disease or improving the diagnosis. Additionally, speakers will address the methodological issues involved including discussion of problems and confounding factors, and provide an outlook for the future, indicating where improved techniques would help clinically.
9:15	Pediatric and Neurodevelopment Pratik Mukherjee, M.D., Ph.D., Radiology, University of California, San Francisco, CA, USA
9:45	Neurological (MS) *Roland G. Henry, Ph.D., University of California, San Francisco, CA, USA*
10:15	Break
10:30	Neurological (stroke) Lawrence Latour, Ph.D., NINDS, National Institutes of Health, Bethesda, MD, USA
11:00	Neurological (tumors, tissue characterization, and surgical planning) Jeffry R. Alger, Ph.D., University of California, Los Angeles, California, USA
11:30	Psychiatric, Cognition, and Neurodegenerative Diseases - not available Kelvin O. Lim, M.D., Psychiatry, University of Minnesota, Minneapolis, MN, USA
12:10	Panel Discussion
12:30	Lunch Break
SESSION 2: Strategies for Diffusion MRI Acquisition
Image Acquisition (MR sequences) - Pros and Cons
13:30	What are the pros and cons of parallel imaging in diffusion? Roland Bammer, Ph.D., Radiology, Stanford University, Palo Alto, CA, USA
14:00	What are the pros and cons of non-EPI and multi-shot diffusion image acquisition strategies? *James Pipe, Ph.D., Barrows Neurological Institute, Phoenix, AZ, USA*
14:30	What are the pros and cons of diffusion imaging at high magnetic field: 3T and beyond? *Peter van Gelderen, Ph.D., National Institutes of Health, Bethesda, MD, USA*
15:00	Is there useful clinical information in very high b-value acquisitions? Stephan Maier, M.D., Ph.D., Radiology, Brigham and Womens Hospital, Boston, MA, USA
15:30	Panel Discussion
16:00	Break
16:15	Poster Session 1
18:30	Dinner
Monday, 14 March
07:30	Breakfast
SESSION 2: Strategies for Diffusion MRI Acquisition, cont.
Experimental design/optimization, artifacts, physiological noise
08:00	What are the best acquisition parameters for diffusion imaging, for a range of specific applications? A framework for defining optimal b-values, directions, SNR, etc. Daniel Alexander, Ph.D., Computer Science, University College London, London, England, UK
08:30	How does physiological noise contaminate diffusion data, and what can we do about it? (Subject motion, cardiac pulsation) **Carlo Pierpaoli, M.D., Ph.D., National Institutes of Health, Bethesda, MD, USA**
09:00	How important are CSF contamination and FLAIR acquisitions in quantitative diffusion measurements? **Christian Beaulieu, Ph.D., University of Alberta, Edmonton, Alberta, Canada**
09:30	What quality control procedures should we be adopting for single- and multi-center studies? And what should the minimal reporting requirements be? - not available D. Louis Collins, Ph.D., Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
10:30 Breakout Sessions 1 (signup for breakout sessions is available when registering online):
	Acquisition - Sequences
	Acquisition - Optimization
	Biological interpretation of diffusion MRI findings
	Tractography
12:00	Lunch Break
SESSION 3: Diffusion Post-Processing
13:00	How can we evaluate the realiability and errors in the calculation of diffusion tensor parameters? Adam W. Anderson, Ph.D., Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
13:30	What are the practical issues of DTI analysis (e.g. ROI placement, histograms, etc.)? *Mara Cercignani, M.Phil., Institute of Neurology, London, England, UK*
14:00	How can we be sure that our statistical analyses are appropriate for our diffusion MR data? Sinisa Pajevic, Ph.D., CIT, National Institutes of Health, Bethesda, MD, USA
14:30	Break
15:00	Correction of distortions on diffusion images: is it needed and what is its effect on data analysis? Jesper Andersson, Ph.D., Karolinska Institute, Stockholm, Sweden
15:30	Analysis of spatially normalized DTI **Derek K. Jones, Ph.D., Institute of Psychiatry, London, England, UK**
16:00	Panel Discussion
16:15 Breakout Sessions 2 (signup for breakout sessions is available when registering online):
	Artifact minimization
	Analysis of DT-MRI data
	Standardization
	Alternatives to the Tensor Model
18:00	Dinner
After dinner presentation
19:30	Why is the study of brain white matter tracts important and how can it be done? A survey of existing and emerging non-MRI methods for 2D and 3D measurement of structural and functional anatomy of brain white matter? Hubertus Axer, University Hospital of the Friedrich-Schiller-University, Jena, German
Tuesday, 15 March
07:30	Breakfast
SESSION 4: Diffusion Tensor Tractography
08:00	To what extent can DTI tractography by validated anatomically? Susumu M. Mori, Ph.D., Radiology, Johns Hopkins University, Baltimore, MD, USA
08:30	What are the errors and constraints in tractography algorithms? Andrew L. Alexander, Ph.D., Medical Physics, University of Wisconsin, Madison, WI, USA
09:00	Head to head tractography algorithms: Do they give the same answer (common datasets, testing/comparisons)? *Sean Deoni, B.Sc., Institute of Psychiatry, Kings College, London, England, UK*
09:30	How can tractography help us to perform quantitative intra- and inter-subject comparisons? *Timothy Behrens, FMRIB, Oxford University, Oxford, England, UK*
10:00	Break
10:30	What form should a DT-MRI atlas take (both vectoral and nonvectoral approaches)? *Christos Davatzikos, Ph.D., University of Pennsylvania, Philadelphia, PA, USA*
11:00	High angular resolution diffusion imaging: What are the pros, cons, and steps towards clinical feasibility?- not available *David S. Tuch, Ph.D., Martinos Center, Radiology, Massachusetts General Hospital, Charlestown, MA, USA*
11:30	Is there any value in studying diffusion anisotropy in the cortex? **Alex de Crespigny, Ph.D., Massachusetts General Hospital, Charlestown, Massachusetts, USA**
12:00	What can we learn by combining DTI and fMRI? *Dae-Shik Kim, Ph.D., Anatomy & Physiology, Boston University, Boston, MA, USA*
12:30	Panel Discussion
12:45	Lunch Break
13:45	Poster Session 2
16:00	Vendor Sessions:
The aim of this session is for the major clinical MRI vendors to present their "roadmap" for clinical diffusion imaging, and provide an opportunity for discussion of the important features for a clinical diffusion MRI product.
17:00	Presentation of the results of the breakout sessions and adjournment **Carlo Pierpaoli, M.D., Ph.D., National Institutes of Health, Bethesda, Maryland, USA**
18:30	Dinner
Wednesday, 16 March
Breakfast and departure